AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation
AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation
复制标题
糖尿病、胰岛素抵抗及糖尿病并发症中的AMPK信号通路：一项临床前与临床研究
DOI：
10.1016/j.biopha.2021.112563
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发表时间：
2022-02-01
影响因子：
7.5
通讯作者：
Samarghandian, Saeed
中科院分区：
文献类型：
--
作者：
Entezari, Maliheh;Hashemi, Danial;Samarghandian, Saeed
糖尿病(DM)在发展中国家和发达国家都被认为是一个主要的挑战，因为生活方式已经改变，其管理似乎至关重要。I型和II型糖尿病是主要类型，它们会导致患者的高血糖和相关的并发症。基因表达异常可导致糖尿病及相关并发症的发生。AMP激活的蛋白激酶(AMPK)是一种能量感受器，在癌症、心血管疾病和糖尿病等多种疾病中都有异常表达。现就AMPK在糖尿病中的作用作一综述。诱导AMPK信号通路可促进糖尿病患者的血糖水平，这对改善高血糖状态具有重要意义。进一步的研究揭示了AMPK信号在糖尿病患者治疗中增强胰岛素敏感性的作用。此外，AMPK的上调抑制了β细胞的应激和细胞死亡，这对预防I型糖尿病的发生具有重要意义。对糖尿病患者的临床研究表明，AMPK信号在改善糖尿病并发症(如脑部疾病)方面发挥了作用。此外，AMPK还可以改善糖尿病期间发生的神经病变、肾病、肝脏疾病和生殖改变。为了发挥这种保护作用，AMPK信号与其他分子通路相互作用，如PGC-
Diabetes mellitus (DM) is considered as a main challenge in both developing and developed countries, as lifestyle has changed and its management seems to be vital. Type I and type II diabetes are the main kinds and they result in hyperglycemia in patients and related complications. The gene expression alteration can lead to development of DM and related complications. The AMP-activated protein kinase (AMPK) is an energy sensor with aberrant expression in various diseases including cancer, cardiovascular diseases and DM. The present review focuses on understanding AMPK role in DM. Inducing AMPK signaling promotes glucose in DM that is of importance for ameliorating hyperglycemia. Further investigation reveals the role of AMPK signaling in enhancing insulin sensitivity for treatment of diabetic patients. Furthermore, AMPK upregulation inhibits stress and cell death in beta cells that is of importance for preventing type I diabetes development. The clinical studies on diabetic patients have shown the role of AMPK signaling in improving diabetic complications such as brain disorders. Further-more, AMPK can improve neuropathy, nephropathy, liver diseases and reproductive alterations occurring during DM. For exerting such protective impacts, AMPK signaling interacts with other molecular pathways such as PGC-