Bimanual coordination dysfunction in early, untreated Parkinson's disease
Bimanual coordination dysfunction in early, untreated Parkinson's disease
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DOI：
10.1016/j.parkreldis.2006.01.006
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发表时间：
2006-01-01
影响因子：
4.1
通讯作者：
Berendse, Henk W.
中科院分区：
文献类型：
--
作者：
Ponsen, Mirthe M.;Daffertshofer, Andreas;Berendse, Henk W.
双手协调包括双手同时进行对称（同相位）或不对称（反相位）运动，已知在帕金森病（PD）中受损。目前尚不清楚在早期未经治疗的PD患者中，这方面的运动功能是否已经受损。因此，我们调查了13名早期未经治疗的PD患者和13名年龄和性别匹配的健康对照者的双手协调的准确性。每个受试者在两种不同的运动频率（1和1.75 Hz）和两种不同的相位关系（同相和反相）下进行双手协调任务。PD患者试验失败的百分比（作为衡量整体任务表现的指标）显著高于健康受试者。PD患者用非优势手执行高频的同相和反相双手协调任务的准确性低于健康受试者。此外，PD患者在低运动频率的反相位状态下比健康者更难以维持手间的恒定相位关系。本研究表明，双手协调功能障碍是帕金森病的早期症状。双手协调任务，特别是那些涉及高频反相位运动，可能在PD的早期诊断中被证明是有用的。(c) 2006 Elsevier Ltd.版权所有。
Bimanual coordination involves the simultaneous performance of either symmetrical (in-phase) or asymmetrical (anti-phase) movements with both hands and is known to be impaired in Parkinson's disease (PD). At present, it is unclear whether this aspect of motor function is already impaired in early stage, untreated PD patients. Therefore, we investigated the accuracy of bimanual coordination in 13 early stage, untreated PD patients and 13 age- and sex-matched healthy controls. Each subject performed bimanual coordination tasks at two different movement frequencies (1 and 1.75 Hz) and with two different phase relationships (in-phase and anti-phase). The percentage of unsuccessful trials (as a measure of overall task performance) in PD patients was significantly higher than in healthy subjects. PD patients performed high frequency in-phase and anti-phase bimanual coordination tasks less accurately with their non-dominant hand than healthy subjects. Furthermore, PD patients had more difficulty than healthy subjects in maintaining a constant phase relationship between the hands in the anti-phase condition at low movement frequency. This study demonstrates that bimanual coordination dysfunction is a very early sign of PD. Bimanual coordination tasks, in particular those involving high frequency anti-phase movements, might prove useful in the early diagnosis of PD. (c) 2006 Elsevier Ltd. All rights reserved.