Account - Chemical cross-linking. and mass spectrometry as structure determination tools
Account - Chemical cross-linking. and mass spectrometry as structure determination tools
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DOI：
10.1255/ejms.868
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发表时间：
2007-01-01
影响因子：
1.3
通讯作者：
Giannakopulos, Anastassios E.
中科院分区：
文献类型：
--
作者：
Novak, Petr;Giannakopulos, Anastassios E.
Chemical cross-linking is becoming a valuable tool for the high-order structure determination of proteins and protein complexes. Cross-linking methodology is able to provide low-resolution structures when at least something is known already about the proteins under investigation. The suitability of top-down and bottom-up methodologies is discussed and further potential applications of chemical cross-linking of proteins, as well as combinations with other techniques such as hydrogen/deuterium exchange and molecular modeling, are suggested.
