EFFECTS OF CANCER CHEMOTHERAPEUTIC AGENTS ON DEHYDROGENASE ACTIVITY OF HUMAN CANCER TISSUE INVITRO
EFFECTS OF CANCER CHEMOTHERAPEUTIC AGENTS ON DEHYDROGENASE ACTIVITY OF HUMAN CANCER TISSUE INVITRO
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DOI：
10.1093/ajcp/23.3.218
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发表时间：
1953-01-01
影响因子：
3.5
通讯作者：
SPEER, FD
中科院分区：
文献类型：
--
作者：
BLACK, MM;SPEER, FD
测定了不同形态的人癌组织的脱氢酶活性。采用四唑盐技术，评价肿瘤化疗药物的体外药效。这些研究提出了以下概括：(A)来自同一类型癌症的个体患者的癌症组织之间存在确定的差异性。(B)癌组织的体外内源性脱氢酶活性与其临床行为之间没有明显的相关性。(C)乌拉坦对癌症组织脱氢酶活性的体外影响似乎与组织的辐射敏感性平行。(D)化疗药物的组合有时会增强单一成分的体外抑制作用。
The dehydrogenase activity of diverse forms of human cancer tissue was detd. by means of the tetrazolium technic, and the in vitro effects of cancer chemotherapeutic agents were evaluated. These studies suggested the following generalizations: (a) There is a decided variability between cancer tissues from individual patients having the same type of cancer. (b) There is no apparent correlation between the intensity of the in vitro endogenous dehydrogenase activity of the cancer tissue and its clinical behavior. (c) The in vitro effect of urethane on the dehydrogenase activity of cancer tissue appears to parallel the radiosensitivity of the tissues. (d) Combinations of chemotherapeutic agents sometimes enhance the in vitro inhibitory effect of a single constituent.