Estrogen improves response accuracy and attenuates the disruptive effects of Δ9-THC in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance
Estrogen improves response accuracy and attenuates the disruptive effects of Δ9-THC in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance
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DOI：
10.1037//07.5-7044.116.6.989
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发表时间：
2002-12-01
影响因子：
1.9
通讯作者：
Moerschbaecher, JM
中科院分区：
文献类型：
--
作者：
Daniel, JM;Winsauer, PJ;Moerschbaecher, JM
尽管有证据表明大麻素和雌激素在大脑中相互作用，但关于这种相互作用对行为的影响的信息很少。使用受试者内设计来检查雌激素和Delta（9）-四氢大麻酚（Delta（9）-THC）对卵巢切除大鼠在重复获取和表现的多个时间表下响应的学习和记忆的影响。用低生理水平的雌激素治疗，在硅橡胶胶囊中递送，提高了应答准确性，而不影响采集期间的应答率。雌激素还减弱了Delta（9）-THC（0.56-3.2 mg/kg）降低获取期间的响应准确度和速率以及执行期间的响应准确度的能力。结果表明，雌激素可以提高非空间操作任务的准确性，并可以减轻Delta（9）-THC诱导的行为缺陷。
Despite evidence of an interaction between cannabinoids and estrogen in the brain, little information is available regarding the consequences of this interaction on behavior. A within-subjects design was used to examine the effects of estrogen and Delta(9)-tetrahydrocannabinol (Delta(9)-THC) on learning and memory in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance. Treatment with low physiological levels of estrogen, delivered in Silastic capsules, improved response accuracy without affecting response rate during acquisition. Estrogen also attenuated the ability of Delta(9)-THC (0.56-3.2 mg/kg) to decrease response accuracy and rate during acquisition and response accuracy during performance. Results indicate that estrogen can improve accuracy during acquisition of a nonspatial operant task and can attenuate Delta(9)-THC- induced behavioral deficits.