Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma
Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma
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DOI：
10.1046/j.1365-2141.2003.04216.x
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发表时间：
2003-03-01
影响因子：
6.5
通讯作者：
Tanimoto, M
中科院分区：
文献类型：
--
作者：
Fujii, K;Ishimaru, F;Tanimoto, M
在之前的研究中，我们证实了转录因子Ikaros的显性阴性亚型在慢性髓性白血病和b细胞急性淋巴细胞白血病（ALL）的原细胞危象患者中过表达。最近，我们报道了Ikaros基因家族成员之一的Helios短亚型在t细胞ALL患者中的过表达。在目前的研究中，我们发现Helios短同种异构体在患有慢性和急性成人T细胞白血病/淋巴瘤的人T淋巴细胞病毒i （HTLV1）感染患者中过表达。相比之下，我们在健康HTLV1携带者中未检测到Helios短亚型的过表达。通过Southern blotting，我们在成人t细胞白血病/淋巴瘤患者的Helios基因位点检测到一个小的缺失。提示Helios基因异常可能是HTLV1感染疾病进展的重要机制之一。
In previous studies, we demonstrated an over-expression of the dominant-negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B-cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over-expression of the short isoforms of Helios , which is one of the members of the Ikaros gene family, in a patient with T-cell ALL. In the present study, we found over-expression of short isoforms of Helios in human T lymphotropic virus-I (HTLV1)-infected patients who had developed chronic and acute forms of adult T-cell leukaemia/lymphoma. In contrast, we could not detect any over-expression of short isoforms of Helios in healthy HTLV1 carriers. By Southern blotting, we detected a small deletion in the Helios gene locus of adult T-cell leukaemia/lymphoma patients. The present results suggest that Helios gene abnormalities might be one of the important mechanisms in the disease progression of HTLV1 infection.