Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid.
Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid.
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肌萎缩侧索硬化症：通过大麻素治疗延缓小鼠疾病进展。
DOI：
10.1080/14660820310016813
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Abood,MaryE
中科院分区：
文献类型：
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作者：
Raman,Chandrasekaran;McAllister,SeanD;Rizvi,Gulrukh;Patel,SonalG;Moore,DanH;Abood,MaryE
Effective treatment for amyotrophic lateral sclerosis (ALS) remains elusive. Two of the primary hypotheses underlying motor neuron vulnerability are susceptibility to excitotoxicity and oxidative damage. There is rapidly emerging evidence that the cannabinoid receptor system has the potential to reduce both excitotoxic and oxidative cell damage. Here we report that treatment with Δ9‐tetrahydrocannabinol (Δ9‐THC) was effective if administered either before or after onset of signs in the ALS mouse model (hSODG93Atransgenic mice). Administration at the onset of tremors delayed motor impairment and prolonged survival in Δ9‐THC treated mice when compared to vehicle controls. In addition, we present an improved method for the analysis of disease progression in the ALS mouse model. This logistic model provides an estimate of the age at which muscle endurance has declined by 50% with much greater accuracy than could be attained for any other measure of decline.In vitro, Δ9‐THC was extremely effective at reducing oxidative damage in spinal cord cultures. Additionally, Δ9‐THC is anti‐excitotoxicin vitro. These cellular mechanisms may underlie the presumed neuroprotective effect in ALS. As Δ9‐THC is well tolerated, it and other cannabinoids may prove to be novel therapeutic targets for the treatment of ALS.
