INVERSE ASSOCIATION BETWEEN SERUM TOTAL CHOLESTEROL AND CANCER MORTALITY IN DUTCH CIVIL-SERVANTS
INVERSE ASSOCIATION BETWEEN SERUM TOTAL CHOLESTEROL AND CANCER MORTALITY IN DUTCH CIVIL-SERVANTS
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DOI：
10.1093/oxfordjournals.aje.a116769
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发表时间：
1993-05-01
影响因子：
5
通讯作者：
KOK, FJ
中科院分区：
文献类型：
--
作者：
SCHUIT, AJ;VANDIJK, CEMJ;KOK, FJ
研究人员对3,091名40-65岁的荷兰公务员及其配偶进行了为期28年的随访研究，调查了血清总胆固醇与癌症死亡率之间的关系。校正年龄、体重指数和吸烟后，在随访的前15年（不包括前2年），观察到男性血清总胆固醇与所有癌症死亡率之间呈负相关：胆固醇最低五分位数与最高五分位数的多变量率比为2.1（95%置信区间（CI）1.1 - 4.0）;这种关联主要由胃肠道癌症（RR = 4.2，95% CI 1.4-12.9）解释。随访16-28年，所有癌症死亡率的多变量率比为0.8（95%CI 0.5-1.4）。在女性中，没有观察到血清总胆固醇和癌症之间的一致性关联。在排除前5年的随访后，男性中的显著负相关仍然存在。这些结果表明，在本研究人群中，低血清胆固醇似乎不是由于未检测到的癌症，但可能是男性癌症死亡率的危险因素。
The association between serum total cholesterol and cancer mortality was investigated in a 28-year follow-up study of 3,091 Dutch civil servants aged 40-65 years and their spouses. After adjustment for age, body mass index, and smoking, an inverse association between serum total cholesterol and all-cancer mortality was observed in men during the first 15 years of follow-up, excluding the first 2 years: The multivariate rate ratio of those in the lowest cholesterol quintile compared with those in the highest quintile was 2.1 (95% confidence interval (CI) 1.1 -4.0); this association was accounted for mainly by gastrointestinal cancers (RR = 4.2, 95% CI 1.4-12.9). For follow-up years 16-28, the multivariate rate ratio for all-cancer mortality was 0.8 (95% CI 0.5-1.4). In women, no consistent association between serum total cholesterol and cancer was observed. After the first 5 years of follow-up were excluded, the significant inverse association in men still persisted. These results suggest that in this study population, low serum cholesterol seems not to be attributable to undetected cancer, but might be a risk factor for cancer mortality in men.