Analysis of factors influencing pancreatic β-cell function in Japanese patients with type 2 diabetes: Association with body mass index and duration of diabetic exposure
Analysis of factors influencing pancreatic β-cell function in Japanese patients with type 2 diabetes: Association with body mass index and duration of diabetic exposure
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DOI：
10.1016/j.diabres.2008.09.010
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发表时间：
2008-12-01
影响因子：
5.1
通讯作者：
Inagaki, Nobuya
中科院分区：
文献类型：
--
作者：
Funakoshi, Shogo;Fujimoto, Shimpei;Inagaki, Nobuya
目的：分析2型糖尿病患者血清c肽免疫反应性（CPR）水平，探讨影响β细胞功能的临床因素。方法：招募了700名日本2型糖尿病患者。通过空腹心肺复苏术（FCPR）、静脉注射1 mg胰高血糖素后6 min （CPR-6 min）和增量心肺复苏术（Delta CPR）评估β细胞功能。对FCPR、CPR-6 min、Delta CPR进行简单回归分析、变量测量及逐步多元回归分析。结果：诊断年龄和BMI是预测β细胞功能的主要独立变量。诊断时间与CPR-6 min呈负相关（P < 0.0001, r = -0.271）， CPR-6 min降低0.050 ng/（ml年）。BMI与CPR-6 min呈正相关（P < 0.0001, r = 0.369）。按BMI分组时，高BMI组CPR-6 min /年的下降幅度（0.068 ng/（ml年））大于低BMI组（0.035 ng/（ml年））。结论：这项横断面研究证实，几十年来糖尿病患者的内源性胰岛素分泌呈线性下降。因此，糖尿病暴露时间和BMI是影响日本2型糖尿病患者β细胞功能的主要因素。2008爱思唯尔爱尔兰有限公司版权所有。
Aims: To elucidate the clinical factors affecting beta-cell function, serum C-peptide immunoreactivity (CPR) levels of patients with type 2 diabetes were analyzed.Methods: Seven hundred Japanese patients with type 2 diabetes were enrolled. beta-Cell function was evaluated by fasting CPR (FCPR), 6 min after intravenous injection of 1 mg glucagon (CPR-6 min), and the increment of CPR (Delta CPR). Simple regression analysis between FCPR, CPR-6 min, and Delta CPR and measures of variables and stepwise multiple regression analysis were carried out.Results: Years from diagnosis and BMI were the major independent variables predicting beta-cell function. Years from diagnosis was negatively correlated with CPR-6 min (P < 0.0001, r = -0.271), and decrease in CPR-6 min was 0.050 ng/(ml year). BMI was positively correlated with CPR-6 min (P < 0.0001, r = 0.369). When subjects were divided according to BMI, the decrease in CPR-6 min per year in the high-BMI group (0.068 ng/(ml year)) was greater than that in the low-BMI group (0.035 ng/(ml year)).Conclusion: A linear decline in endogenous insulin secretion over more than several decades of diabetes was confirmed by this cross-sectional study. The duration of diabetes exposure and BMI are thus major factors in beta-cell function in Japanese patients with type 2 diabetes. (c) 2008 Elsevier Ireland Ltd. All rights reserved.