Unfolded Protein Response in Lung Health and Disease
Unfolded Protein Response in Lung Health and Disease
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DOI：
10.3389/fmed.2020.00344
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发表时间：
2020-07-30
影响因子：
3.9
通讯作者：
Barabutis, Nektarios
中科院分区：
文献类型：
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作者：
Barabutis, Nektarios
未折叠蛋白反应（UPR）是一个复杂的因素，注定要保护细胞免受各种细胞外和细胞内的挑战。UPR激活设计了高效的反应来抵消细胞威胁。如果这些活动失败，它将指示细胞执行。目前的研究重点是UPR在肺功能中的作用，通过深入研究内皮屏障功能的高度相关网络。高度复杂的普遍定期审议操作将揭示针对炎症性肺病（如急性肺损伤和急性呼吸窘迫综合征）的新的治疗可能性。
The unfolded protein response (UPR) is a complex element, destined to protect the cells against a diverse variety of extracellular and intracellular challenges. UPR activation devises highly efficient responses to counteract cellular threats. If those activities fail, it will dictate cellular execution. The current work focuses on the role of UPR in pulmonary function, by immersing into the highly interrelated network that operates toward the endothelial barrier function. A highly sophisticated UPR manipulation shall reveal new therapeutic possibilities against inflammatory lung disease, such as acute lung injury and acute respiratory distress syndrome.