Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(tert-butylamino)ethyl Methacrylate-b-poly(ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier
Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(tert-butylamino)ethyl Methacrylate-b-poly(ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier
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DOI：
10.3390/molecules25010195
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发表时间：
2020-01-01
期刊：
影响因子：
4.6
通讯作者：
Almeataq, Mohammed S.
中科院分区：
文献类型：
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作者：
Alswieleh, Abdullah M.;Beagan, Abeer M.;Almeataq, Mohammed S.
采用原子转移自由基聚合法（ATRP）将甲基丙烯酸叔丁氨基乙酯-聚乙二醇甲醚甲基丙烯酸酯嵌段共聚物（PTBAEMA-b-PEGMEMA-MSNs）接枝到介孔二氧化硅纳米粒子上，合成了一种新型的介孔二氧化硅纳米粒子。首先将ATRP引发剂连接到MSN表面，然后进行甲基丙烯酸2-（叔丁基氨基）乙酯（PTBAEMA）的ATRP。CuBr 2/bipy和抗坏血酸分别用作催化剂和还原剂，以生长第二聚合物，聚（乙二醇）甲基醚甲基丙烯酸酯（PEGMEMA）。这些制造的纳米材料的表面结构，然后使用傅里叶变换红外（FTIR）光谱分析。热重分析（TGA）结果表明，ATRP可以为聚合物提供高的表面接枝密度。采用动态光散射（DLS）研究了纳米颗粒表面两嵌段共聚物链的pH响应行为。此外，多功能pH敏感性PTBAEMA-b-PEGMEMA-MSNs负载多西环素（Doxy），以研究其容量和长循环时间。
This paper introduces the synthesis of well-defined 2-(tert-butylamino)ethyl methacrylate-b-poly(ethylene glycol) methyl ether methacrylate diblock copolymer, which has been grafted onto mesoporous silica nanoparticles (PTBAEMA-b-PEGMEMA-MSNs) via atom transfer radical polymerization (ATRP). The ATRP initiators were first attached to the MSN surfaces, followed by the ATRP of 2-(tert-butylamino)ethyl methacrylate (PTBAEMA). CuBr2/bipy and ascorbic acid were employed as the catalyst and reducing agent, respectively, to grow a second polymer, poly(ethylene glycol) methyl ether methacrylate (PEGMEMA). The surface structures of these fabricated nanomaterials were then analyzed using Fourier Transform Infrared (FTIR) spectroscopy. The results of Thermogravimetric Analysis (TGA) show that ATRP could provide a high surface grafting density for polymers. Dynamic Light Scattering (DLS) was conducted to investigate the pH-responsive behavior of the diblock copolymer chains on the nanoparticle surface. In addition, multifunctional pH-sensitive PTBAEMA-b-PEGMEMA-MSNs were loaded with doxycycline (Doxy) to study their capacities and long-circulation time.