Increased iron deposition of deep cerebral gray matter structures in hemodialysis patients: A longitudinal study using quantitative susceptibility mapping
Increased iron deposition of deep cerebral gray matter structures in hemodialysis patients: A longitudinal study using quantitative susceptibility mapping
复制标题
血液透析患者大脑深部灰质结构铁沉积增加：使用定量磁化率图的纵向研究
DOI：
10.1002/jmri.26226
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发表时间：
2019-03-01
影响因子：
4.4
通讯作者：
Shen, Wen
中科院分区：
文献类型：
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作者：
Chai, Chao;Wang, Huiying;Shen, Wen
研究背景血液透析患者存在脑铁超载，横断面分析可能影响对铁含量变化的评价。目的应用定量磁敏感性图（QSM）研究血液透析患者脑铁沉积的纵向变化，并将这些结果与神经认知功能的纵向变化及临床因素相关联。研究类型前瞻性;共34例患者和30例健康对照者（HC）;采用场强/序列3.0T磁敏感加权成像（SWI），利用SWI原始相位数据重建的QSM评价双侧尾状核（CN）、苍白球（GP）、尾状核（PUT）、尾状核（CN）、苍白球（GP）、尾状核（PU）、尾状核（PU）、尾状核（PU）、尾状核（PU）等灰质结构的磁敏感性。红核（RN）、黑质（SN）、齿状核（DN）、丘脑（THA）、丘脑枕（PT）。记录简易精神状态检查（MMSE）测试和临床因素。统计学检验协方差分析调整年龄和性别作为协变量或配对t检验的敏感性，MMSE评分，和临床因素之间的差异基线，随访患者，和HC。结果随访组患者双侧CN、GP、PUT、RN、SN、DN、THA、PT的易感性均显著高于基线组（P
BackgroundThe cerebral iron overload in hemodialysis patients has been reported in a previous study, in which the evaluation of the changes in iron content could be affected by the cross-sectional analysis.PurposeTo investigate the longitudinal changes of iron deposition in hemodialysis patients using quantitative susceptibility mapping (QSM) and correlate these findings with the longitudinal changes of neurocognitive function and clinical factors.Study TypeProspective; longitudinal.PopulationIn all, 34 patients and 30 healthy controls (HCs); the mean follow-up interval was 227 months.Field Strength/Sequence3.0T, susceptibility-weighted imaging (SWI).AssessmentQSM reconstructed from original phase data of SWI was used to measure the susceptibility of gray matter structures including bilateral caudate nucleus (CN), globus pallidus (GP), putmen (PUT), red nucleus (RN), substantia nigra (SN), dentate nucleus (DN), thalamus (THA), pulvinar of thalamus (PT). The Mini-Mental State Examination (MMSE) test and clinical factors were recorded.Statistical TestingAnalysis of covariance adjusting for age and gender as covariates or a paired t-test for the differences in susceptibility, MMSE scores, and clinical factors among baseline, follow-up patients, and HCs. Correlation and stepwise regression analysis for the relationship between susceptibility, MMSE scores, and clinical factors.ResultsThe susceptibility of bilateral CN, GP, PUT, RN, SN, DN, THA, PT in follow-up patients was significantly higher than that in baseline between patients and HCs except for left THA (all P