Normal values for aortic diameters in children and adolescents assessment in vivo by contrast-enhanced CMR-angiography
Normal values for aortic diameters in children and adolescents assessment in vivo by contrast-enhanced CMR-angiography
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DOI：
10.1186/1532-429x-10-56
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发表时间：
2008-12-05
影响因子：
6.4
通讯作者：
Buechel, Emanuela R. Valsangiacomo
中科院分区：
文献类型：
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作者：
Kaiser, Thomas;Kellenberger, Christian J.;Buechel, Emanuela R. Valsangiacomo
背景：对比增强CMR血管造影（CE-CMRA）越来越多地用于主动脉弓异常的诊断、干预计划和随访评估。我们试图用CE-CMRA建立儿童胸主动脉直径的正常值和与身体生长相关的参考曲线。结果：对53例无心血管疾病的儿童行CE-CMRA检查。年龄中位数为9岁（范围2-20岁），体重30 kg（范围12-75 kg），身高131 cm（范围81-184 cm），体表面积1.05 m（范围0.52-1.9 m(2)）。在倾斜最大强度投影（MIP）图像上测量9个标准化部位的主动脉直径。主动脉直径与BSA关系的回归分析显示，主动脉横切面直径与BSA平方根呈线性关系（BSA(0.5)）。主动脉窦的标准直径为（0.57 + 19.37*BSA(0.5)） mm，主动脉弓第一段为（-3.52 + 18.66*BSA(0.5)） mm，峡区为（-3.37 + 16.52*BSA(0.5)） mm，横膈水平降主动脉为（-1.27 + 9.89*BSA(0.5)） mm。给出了规范曲线。结论：本研究提供了CE-CMRA测量儿童主动脉直径的规范性值。这些数据可能有助于诊断儿童弓异常，评估治疗的需要和计划干预措施。
Background: Contrast-enhanced CMR angiography (CE-CMRA) is being increasingly used for diagnosing aortic arch anomalies, planning interventions and follow-up assessment. We sought to establish normal values for the diameters of the thoracic aorta and reference curves related to body growth in children using CE-CMRA.Results: CE-CMRA was performed in 53 children without cardiovascular disease. The median age was 9 years (range 2-20 years), weight 30 kg (range 12-75 kg), height 131 cm (range 81-184 cm), body surface area (BSA) 1.05 m(2) (range 0.52-1.9 m(2)). Aortic diameters were measured at nine standardized sites on oblique maximum-intensity projection (MIP) images. Regression analysis of diameters in relation to BSA demonstrated linear relationship between the cross-sectional aortic diameters and the square root of BSA (BSA(0.5)). Normative diameters were (0.57 + 19.37*BSA(0.5)) mm for the aortic sinus, (-3.52 + 18.66*BSA(0.5)) mm for the first segment of the aortic arch, (-3.37 + 16.52*BSA(0.5)) mm for the isthmic region and (-1.27 + 9.89*BSA(0.5)) mm for the descending aorta at the level of the diaphragm. Normative curves are presented.Conclusion: This study provides normative values for aortic diameters in children measured by CE-CMRA. These data may serve for making the diagnosis of pediatric arch anomalies, assessing the need for treatment and planning interventions.