Short-term outcomes after brief ambulatory opioid detoxification with buprenorphine in young heroin users
Short-term outcomes after brief ambulatory opioid detoxification with buprenorphine in young heroin users
复制标题
DOI：
10.1046/j.1360-0443.2003.00334.x
复制
发表时间：
2003-04-01
期刊：
影响因子：
6
通讯作者：
Currens, M
中科院分区：
文献类型：
--
作者：
Gandhi, DH;Jaffe, JH;Currens, M
目的本研究探讨在非常短暂的门诊戒毒丁丙诺啡在18-25岁的海洛因users.Design前瞻性随访study.Setting门诊戒毒诊所，提供短暂的戒毒在市中心的巴尔的摩，马里兰州。参与者：123名受试者，年龄在18 - 25岁之间，56%为男性，95%为高加索人，寻求戒毒，居住在巴尔的摩市及周边5个县，用丁丙诺啡进行为期3天的戒毒干预。随访1，3和6 months.Measurements药物使用史，成瘾严重程度指数在基线和后续行动，尿液药物屏幕，评价的戒毒experience.Findings通过自我报告，37%的总样本目前没有使用海洛因在1个月，32%在3个月和29%。在6个月时，分别有6.7%、10.1%和11.8%的患者在1、3和6个月时尿液阿片样物质检测呈阴性。与基线相比，平均成瘾严重程度指数吸毒综合评分以及过去30天内使用海洛因和可卡因的平均天数显着下降，并且在三个随访点持续下降。参与善后一般poor.Conclusions的研究结果表明，减少药物使用的频率和强度，这表明可能的作用，为减少依赖的严重程度，为一些年轻的海洛因使用者可能还没有准备好从事长期的禁欲导向或阿片类药物替代治疗的短期门诊戒毒。
Aims This study examines the outcomes at 1, 3 and 6 months after a very brief outpatient detoxification with buprenorphine in 18-25-year-old heroin users.Design Prospective follow-up study.Setting Outpatient drug treatment clinic, providing brief detoxification in downtown Baltimore, Maryland. USA.Participants One hundred and twenty-three subjects between 18 and 25 years old; 56% male; 95% Caucasian; seeking detoxification; living in Baltimore City and five surrounding counties.Intervention Detoxification with buprenorphine over 3 days. Follow-up at 1, 3 and 6 months.Measurements Drug use history, the Addiction Severity Index at baseline and follow-up, urine drug screens, evaluation of the detoxification experience.Findings By self-report, 37% of the total sample were not currently using heroin at 1 month, 32% at 3 months and 29%. at 6 months, and 6.7%, 10.1% and 11.8% had an opioid negative urine test at 1, 3 and 6 months, respectively. There was a significant reduction from the baseline in mean Addiction Severity Index drug use composite score, as well as the mean number of days of heroin and cocaine use during past 30 days, that was sustained over the three follow-up points. Engagement in aftercare was generally poor.Conclusions The findings show a reduced frequency and intensity of drug use, suggesting a possible role for brief outpatient detoxification in reducing the severity of dependence for some younger heroin users who may not yet be ready to engage in long-term abstinence-oriented or opioid substitution treatments.