Identifying changes in scores on the EORTC-QLQ-C30 representing a change in patients' supportive care needs.
Identifying changes in scores on the EORTC-QLQ-C30 representing a change in patients' supportive care needs.
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DOI：
10.1007/s11136-014-0853-y
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发表时间：
2015-05
影响因子：
3.5
通讯作者：
Wu, Albert W.
中科院分区：
文献类型：
--
作者：
Snyder, Claire F.;Blackford, Amanda L.;Sussman, Jonathan;Bainbridge, Daryl;Howell, Doris;Seow, Hsien Y.;Carducci, Michael A.;Wu, Albert W.
关键词：
使用与健康相关的生活质量指标进行患者管理需要了解哪些评分变化需要临床关注。通过与患者报告的支持性护理需求变化进行比较，我们估计了欧洲癌症研究和治疗组织生活质量问卷核心 30 (EORTC-QLQ-C30) 的变化，这些变化代表了重要的变化。这项二次分析使用了来自 28 个加拿大外科诊所的 193 名新诊断癌症患者（63% 为乳腺癌，37% 为结直肠癌；平均年龄 60 岁；20% 男性）的数据。参与者在基线、第 3 周和第 8 周完成了支持性护理需求调查 - 简表 - 34 (SCNS-SF34) 和 EORTC-QLQ-C30。我们根据 SCNS-SF34 计算了与支持性护理需求的改善、恶化和无变化相关的 EORTC-QLQ-C30 评分的平均变化。与 SCNS-SF34 改善和恶化类别相关的 EORTC-QLQ-C30 评分的平均变化用于估计临床重要变化，“无变化”类别用于估计不显着的变化。对于报告支持性护理需求改善的患者，EORTC-QLQ-C30 评分变化范围为 6 至 32 分；统计上显着的变化为10-32分。对于报告支持性护理需求恶化的患者，EORTCQLQ-C30 评分变化范围从恶化 21 分到改善 21 分；统计上显着的变化是假设方向上的 9-21 个点和相反方向上的 21 个点的统计上显着的变化。对于报告稳定支持性护理需求的患者，EORTC-QLQ-C30 评分变化范围从恶化 1 分到改善 16 分。这些数据表明 10 分 EORTC-QLQ-C30 评分变化代表支持性护理需求的变化。在临床使用EORTC-QLQ-C30时，评分变化≥10分应引起临床注意。
Using health-related quality-of-life measures for patient management requires knowing what changes in scores require clinical attention. We estimated changes on the European Organization for Research and Treatment of Cancer Quality-of-Life-Questionnaire-Core-30 (EORTC-QLQ-C30) representing important changes by comparing to patient-reported changes in supportive care needs. This secondary analysis used data from 193 newly-diagnosed cancer patients (63% breast, 37% colorectal; mean age 60 years; 20% male) from 28 Canadian surgical practices. Participants completed the Supportive Care Needs Survey-Short Form-34 (SCNS-SF34) and EORTC-QLQ-C30 at baseline, 3 weeks, and 8 weeks. We calculated mean changes in EORTC-QLQ-C30 scores associated with improvement, worsening, and no-change in supportive care needs based on the SCNS-SF34. Mean changes in the EORTC-QLQ-C30 scores associated with the SCNS-SF34 improved and worsened categories were used to estimate clinically important changes, and the ‘no change’ category to estimate insignificant changes. EORTC-QLQ-C30 score changes ranged from 6 to 32 points for patients reporting improved supportive care needs; statistically significant changes were 10-32 points. EORTCQLQ-C30 score changes ranged from 21-point worsening to 21-point improvement for patients reporting worsening supportive care needs; statistically significant changes were 9-21 points in the hypothesized direction and a 21-point statistically significant change in the opposite direction. EORTC-QLQ-C30 score changes ranged from a 1-point worsening to 16-point improvement for patients reporting stable supportive care needs. These data suggest 10-point EORTC-QLQ-C30 score changes represent changes in supportive care needs. When using the EORTC-QLQ-C30 in clinical practice, scores changing ≥10 points should be highlighted for clinical attention.
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DOI：
10.1007/s11136-010-9636-2
发表时间：
2010-08
期刊：
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
影响因子：
--
作者：
Snyder CF;Blackford AL;Brahmer JR;Carducci MA;Pili R;Stearns V;Wolff AC;Dy SM;Wu AW
通讯作者：
Wu AW
影响因子：
3.6
作者：
Kvam AK;Wisløff F;Fayers PM
通讯作者：
Fayers PM
影响因子：
--
作者：
Snyder, Claire F.;Herman, Joseph M.;Wu, Albert W.
通讯作者：
Wu, Albert W.
影响因子：
45.3
作者：
McLachlan, SA;Allenby, A;Zalcberg, J
通讯作者：
Zalcberg, J
影响因子：
120.7
作者：
Detmar, SB;Muller, MJ;Aaronson, NK
通讯作者：
Aaronson, NK