Mechanosensitivity of pancreatic β-cells, adipocytes, and skeletal muscle cells: the therapeutic targets of metabolic syndrome.
Mechanosensitivity of pancreatic β-cells, adipocytes, and skeletal muscle cells: the therapeutic targets of metabolic syndrome.
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胰腺β细胞、脂肪细胞和骨骼肌细胞的机械敏感性：代谢综合征的治疗靶点。
DOI：
10.1007/978-94-007-5073-9_14
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Ishikawa T
中科院分区：
文献类型：
--
作者：
Nakayama K;Tanabe Y;Obara K;Ishikawa T
机械力信号转导是将机械力/物理力转化为生物化学信号，随后产生各种细胞内信号和细胞反应的分子和细胞过程。已知心血管系统对诸如血压和血流的机械刺激特别敏感。有趣的是，胰腺β细胞、脂肪细胞和骨骼肌细胞，所有这些都与引起心血管疾病的代谢综合征的核心问题有关，也对机械刺激（例如渗透压变化和拉伸）有反应，并且显示出多种功能，包括从β细胞释放胰岛素、抑制脂肪细胞分化和骨骼肌细胞中葡萄糖转运蛋白4（GLUT 4）的易位。此外，鱼油衍生的ω-3多不饱和脂肪酸如二十碳五烯酸（EPA）与周期性拉伸组合显著降低脂肪细胞分化。本文从机械敏感性的角度统一讨论了三个外周器官，这有助于认识生物力学因素在生理和病理条件下的重要性，并可能具有潜在的治疗效果。
Mechanotransduction is the molecular and cellular processes that transduce mechanical/physical forces into biochemical signals followed by diverse intracellular signalings and cell responses. The cardiovascular system is known to be particularly sensitive to mechanical stimuli such as blood pressure and blood flow. Interestingly, pancreatic β-cells, adipocytes, and skeletal muscle cells, all of which are related to the core concerns in metabolic syndrome causing cardiovascular diseases, are also responsive to mechanical stimuli, such as osmotic change and stretching, and show a variety of functions, including insulin release from β-cells, depression of adipocyte differentiation, and translocation of glucose transporter 4 (GLUT4) in skeletal muscle cells. Furthermore, the fish-oil-derived ω-3 polyunsaturated fatty acid such as eicosapentaenoic acid (EPA) combined with cyclic stretching significantly reduces the adipocyte differentiation. The present article is enable to unitarily discuss three peripheral organs from the viewpoint of mechanosensitivity, which aids in recognizing the importance of biomechanical factors in physiological and pathological conditions, and may potentially have therapeutic consequences.