Prenatal environmental exposures, epigenetics, and disease.
Prenatal environmental exposures, epigenetics, and disease.
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DOI：
10.1016/j.reprotox.2010.12.055
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Herbstman J
中科院分区：
文献类型：
--
作者：
Perera F;Herbstman J
本文综述了最近的证据表明，产前暴露于不同的环境化学物质失调的胎儿表观基因组，与随后的发育障碍和疾病表现在儿童期，在生命过程中，甚至transgeneratively的潜在后果。原始生殖细胞、胚胎和胎儿极易受到环境化学物质的表观遗传失调的影响，从而产生多种不良影响。这里审查的数据对环境污染物的风险评估有潜在的影响，虽然需要更多的数据对个人的易感性表观遗传改变和持久性之前，这些信息可以用于正式的风险评估。讨论的结果表明，识别环境化学物质，失调的产前表观基因组应该是健康研究和疾病预防的优先事项。
This review summarizes recent evidence that prenatal exposure to diverse environmental chemicals dysregulates the fetal epigenome, with potential consequences for subsequent developmental disorders and disease manifesting in childhood, over the lifecourse, or even transgenerationally. The primordial germ cells, embryo, and fetus are highly susceptible to epigenetic dysregulation by environmental chemicals, which can thereby exert multiple adverse effects. The data reviewed here on environmental contaminants have potential implications for risk assessment although more data are needed on individual susceptibility to epigenetic alterations and their persistence before this information can be used in formal risk assessments. The findings discussed indicate that identification of environmental chemicals that dysregulate the prenatal epigenome should be a priority in health research and disease prevention.