Effects of zinc supplementation on serum zinc concentration and ratio of apo/ holo-activities of angiotensin converting enzyme in patients with taste impairment
Effects of zinc supplementation on serum zinc concentration and ratio of apo/ holo-activities of angiotensin converting enzyme in patients with taste impairment
复制标题
补锌对味觉障碍患者血清锌浓度及血管紧张素转换酶apo/holo活性比值的影响
DOI：
10.1016/j.anl.2009.07.003
复制
发表时间：
2010
影响因子：
1.7
通讯作者：
S. Yamamoto and N. Takeda
中科院分区：
文献类型：
--
作者：
T. Takaoka;N. Sarukura;C. Ueda;Y. Kitamura;B. Kalubi;N. Toda;K. Abe;S. Yamamoto and N. Takeda
本研究的目的是评价补锌对味觉障碍患者味觉减退、血清锌浓度和血管紧张素转换酶（ACE）活性比值的影响。方法将40例味觉障碍患者分为缺锌性味觉障碍组（n=12）和特发性味觉障碍组（n=28）。锌血症值小于63μg/dl且无其他已知引起味觉障碍的疾病或药物史的患者被诊断为缺锌组，而具有相同条件且值大于64μg/dl的患者被认为属于特发性组。患者每天口服150 mg Polaprezinc（含33 mg锌）。采用视觉模拟评分法（VAS）对患者主观症状进行评分，补锌可改善特发性和缺锌组的味觉减退。特发性组VAS平均改善3.02±3.03，缺锌组VAS平均改善3.13±2.53。因此，在特发性和缺锌组中没有显著差异。缺锌组和特发性缺锌组补锌后VAS评分的改善与ACE比值之间均存在显著相关性。相反，两组补锌后VAS评分的改善与血清锌浓度之间无显著相关性。结论锌缺乏是导致味觉障碍的主要因素，ACE比值可能是补锌后味觉障碍预后的预测因子。此外，锌营养比血清中的锌浓度更敏感。
OBJECTIVEThe aim of the present study was to evaluate the effects of zinc supplementation on hypogeusia, serum zinc concentration and the ratio of apo/holo-activities of angiotensin converting enzyme (ACE ratio) in patients with taste impairment. ACE ratio was used as an index of zinc nutritional status.METHODSForty patients complaining of taste impairment were divided into two groups: zinc deficiency taste impairment (n=12) and idiopathic taste impairment (n=28). Patients with zincemia values of less than 63μg/dl with no history of other disorder or medication known to cause dysgeusia were diagnosed as zinc deficiency group, while those with the same condition and values more than 64μg/dl were considered to belong to the idiopathic group. Patients orally received 150mg of polaprezinc containing 33mg of zinc every day. Subjective symptom was scored according to visual analogue scale (VAS).RESULTSZinc supplementation improved hypogeusia in both idiopathic and zinc deficiency groups. The mean improvements of VAS were 3.02±3.03 in the idiopathic group and 3.13±2.53 in the zinc deficiency group. Thus, there were no significant differences in idiopathic and zinc deficiency groups. Significant correlations were found between the improvement of VAS score and the ACE ratio after zinc supplementation in both idiopathic and zinc deficiency groups. On the contrary, significant correlations were not found between the improvement of VAS score and the zinc concentration in the serum after zinc supplementation in both groups.CONCLUSIONThe results of the present study indicated that zinc deficiency is a predominant factor underlying taste impairment and ACE ratio may be a predictor of the prognosis for taste impairment after zinc supplementation, in addition to a more sensitive indicator of zinc nutrition than zinc concentration in the serum.