Disparate roles of chiral ligands and molecularly imprinted cavities in asymmetric catalysis and chiral poisoning
Disparate roles of chiral ligands and molecularly imprinted cavities in asymmetric catalysis and chiral poisoning
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DOI：
10.1021/om010944c
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发表时间：
2002-01-07
期刊：
影响因子：
2.8
通讯作者：
Gagné, MR
中科院分区：
文献类型：
--
作者：
Koh, JH;Larsen, AO;Gagné, MR
分子印迹金属配合物的活化生成用于烯反应的刘易斯酸催化剂，每个催化剂包含手性双膦配体和手性BINOL形空腔。用（R）-和（S）-BINAM进行的中毒实验表明，虽然手性空腔可以区分手性毒物，但控制烯产物的对映选择性的是手性双膦配体。
The activation of molecularly imprinted metal complexes generates Lewis acid catalysts for the ene reaction, each of which contains a chiral diphosphine ligand and a chiral BINOL-shaped cavity. Poisoning experiments with (R)- and (S)-BINAM indicate that while the chiral cavity can differentiate the chiral poisons, it is the chiral diphosphine ligand which controls the enantioselectivity of the ene product.