Adipose tissue concentrations of persistent organic pollutants and prevalence of type 2 diabetes in adults from Southern Spain
Adipose tissue concentrations of persistent organic pollutants and prevalence of type 2 diabetes in adults from Southern Spain
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DOI：
10.1016/j.envres.2012.12.001
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发表时间：
2013-04-01
影响因子：
8.3
通讯作者：
Olea, Nicolas
中科院分区：
文献类型：
--
作者：
Arrebola, Juan P.;Pumarega, Jose;Olea, Nicolas
越来越多的证据表明，环境因素在2型糖尿病的发展中起着重要作用。几种持久性有机污染物被怀疑是导致2型糖尿病患病率和风险增加的原因。本研究的目的是调查西班牙南部成人样本中三种有机氯农药和三种多氯联苯的身体负担和总体雌激素活性与2型糖尿病风险的关系。从386名接受非癌症相关手术的受试者中获得脂肪组织和血清样本，并使用经过验证的方法提取。采用高分辨率气相色谱-串联质谱联用仪分析持久性有机污染物的残留。利用总有效雌激素负荷（TEXB）生物标志物测量脂肪组织提取物的总体雌激素性。通过面对面访谈和临床记录收集生活方式、饮食习惯和健康状况的数据。采用无条件逻辑回归和不同调整水平进行统计分析。在校正了脂肪组织来源、性别、年龄和体重指数的模型中，脂肪组织中p，p′-二氯二苯二乙烯（p,p′-DDE）浓度的第二和第三分位数与糖尿病风险呈正相关[比值比（95%置信区间）分别为3.6（0.8-17.3）和4.4(1.0-21.0)]。当身体质量指数和脂肪组织来源从模型中剔除时，也发现与β -六氯环己烷呈正相关，暴露的第二和第三十分位数的比值比（95%置信区间）分别为3.3（1.0-10.4）和5.5（1.7-17.3）。此外，p、p'-DDE与体重指数之间存在统计学上显著的相互作用，因此，在非肥胖受试者中，糖尿病的风险随着暴露的分位数呈线性增加，而在肥胖受试者中则没有，在肥胖受试者中观察到倒u型模式。(C) 2012爱思唯尔公司版权所有。
There is increasing evidence that environmental factors play an important role in the development of type 2 diabetes. Several persistent organic pollutants are suspected to contribute to the increasing prevalence and risk of type 2 diabetes. The aim of this study was to investigate the association of the body burden of three organochlorine pesticides and three polychlorinated biphenyls and the overall estrogenic activity with the risk of type 2 diabetes in a sample of adults from Southern Spain.Samples of adipose tissue and serum were obtained from 386 subjects undergoing non-cancer-related surgery and were extracted using validated methodologies. Residues of persistent organic pollutants were analyzed by means of high-resolution gas chromatography with a mass spectrometry detector in tandem mode. The overall estrogenicity of the adipose tissue extracts was measured by using the total effective xenoestrogen burden (TEXB) biomarker. Data on lifestyle, dietary habits, and health status were gathered from face-to-face interviews and clinical records. Statistical analyses were performed with unconditional logistic regression and different adjustment levels.In the models adjusted for adipose tissue origin, sex, age, and body mass index, the 2nd and 3rd tertiles of adipose tissue concentrations of p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) were positively associated with the risk of diabetes [odds ratios (95% confidence interval)=3.6 (0.8-17.3) and 4.4 (1.0-21.0), respectively]. A positive association with beta-hexachlorocyclohexane was also found when body mass index and adipose tissue origin were removed from the models, with odds ratios (95% confidence interval) of 3.3 (1.0-10.4) and 5.5 (1.7-17.3), for the 2nd and 3rd tertiles of exposure, respectively. In addition, a statistically significant interaction was observed between p,p'-DDE and body mass index, such that the risk of diabetes increased with tertiles of exposure in a linear manner in non-obese subjects but not in the obese, in whom an inverted U-shape pattern was observed. (C) 2012 Elsevier Inc. All rights reserved.