Congenital and Perinatal Varicella Infections.
Congenital and Perinatal Varicella Infections.
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DOI：
10.5005/jp-journals-11002-0040
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发表时间：
2022-07
期刊：
影响因子：
--
通讯作者：
Boppana SB
中科院分区：
文献类型：
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作者：
Singh S;Sharma A;Rahman MM;Kasniya G;Maheshwari A;Boppana SB
水痘-带状疱疹病毒是α疱疹病毒家族的一种人类病原体。一些在怀孕8-20周左右在宫内感染的胎儿显示出先天性水痘综合征(CVS)的迹象。母亲在分娩前5天内和分娩后2天内发生水痘的婴儿可能会患上严重的疾病，死亡率增加。最好的诊断方法是聚合酶链式反应(PCR)，可以使用水泡拭子或刮片、结痂病变的结痂、活检样本的组织和脑脊液进行诊断。水痘感染的预防和治疗包括接种疫苗、抗VZV免疫球蛋白和特定的抗病毒药物。本文就VZV的特点、临床表现、围产期感染的处理及近期和远期预后作一综述。
Varicella–zoster virus (VZV) is a human pathogen of the α-herpesvirus family. Some fetuses infected in utero around 8–20 weeks of pregnancy show signs of congenital varicella syndrome (CVS). Infants born to mothers who develop varicella within 5 days before and 2 days after delivery can experience severe disease with increased mortality. The best diagnostic modality is polymerase chain reaction (PCR), which can be done using vesicular swabs or scrapings, scabs from crusted lesions, tissue from biopsy samples, and cerebrospinal fluid. The prevention and management of varicella infections include vaccination, anti-VZV immunoglobulin, and specific antiviral drugs. In this article, we have reviewed the characteristics of VZV, clinical manifestations, management of perinatal infections, and short- and long-term prognosis.