Thermospermine is not a minor polyamine in the plant kingdom.
Thermospermine is not a minor polyamine in the plant kingdom.
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DOI：
10.1093/pcp/pcs019
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发表时间：
2012-04
影响因子：
4.9
通讯作者：
A. Takano;Jun-ichi Kakehi;Taku Takahashi
中科院分区：
文献类型：
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作者：
A. Takano;Jun-ichi Kakehi;Taku Takahashi
热精胺是精胺的结构异构体，精胺是过去广泛研究的多胺之一，并且通过植物中名为ACAULIS 5（ACL 5）的基因编码的热精胺合酶的作用由亚精胺产生。根据最近的基因组测序分析，ACL5样基因广泛分布于整个植物王国。在拟南芥中，ACL5在木质部形成过程中从原形成层细胞到木质部导管的分化过程中特异表达。ACL5功能缺失突变体显示木质部导管沿着过度增殖并伴有严重的矮化，表明热精胺在抑制木质部分化中起作用。acl 5的抑制突变体的研究，恢复野生型表型在没有热精胺的情况下，表明热精胺的行为对特定的mRNA的翻译含有上游开放阅读框（uORF）。热精胺是一种新型的植物生长调节剂，也可用于控制木材生物量的产生。
Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants. According to recent genome sequencing analyses, ACL5-like genes are widely distributed throughout the plant kingdom. In Arabidopsis, ACL5 is expressed specifically during xylem formation from procambial cells to differentiating xylem vessels. Loss-of-function mutants of ACL5 display overproliferation of xylem vessels along with severe dwarfism, suggesting that thermospermine plays a role in the repression of xylem differentiation. Studies of suppressor mutants of acl5 that recover the wild-type phenotype in the absence of thermospermine suggest that thermospermine acts on the translation of specific mRNAs containing upstream open reading frames (uORFs). Thermospermine is a novel type of plant growth regulator and may also serve in the control of wood biomass production.