Persistent spatial information in the frontal eye field during object-based short-term memory.
Persistent spatial information in the frontal eye field during object-based short-term memory.
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DOI：
10.1523/jneurosci.1450-12.2012
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发表时间：
2012-08-08
期刊：
影响因子：
--
通讯作者：
Moore T
中科院分区：
文献类型：
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作者：
Clark KL;Noudoost B;Moore T
空间注意力被认为是进入视觉短期记忆的大门，一些证据表明，空间信号也可能在记忆维持期间在绑定特征或保护对象表征方面发挥作用。为了研究空间信号在物体短时记忆中的持续性，在基于物体的延迟匹配样本（DMS）任务中记录了猕猴额眼区（FEF）神经元的活动。在这项任务中，猴子被训练在短暂的延迟内记住物体图像，而不管样品或目标呈现的位置。FEF神经元表现出视觉，延迟，和目标期活动，包括选择性的样品位置和目标位置。延迟期间的活动代表了整个延迟的样本位置，尽管成功完成任务的空间信息无关。此外，神经元继续编码样本的位置在一个变种的任务，其中匹配的刺激从来没有出现在他们的反应领域，确认FEF保持样本的位置独立于随后的行为相关性。FEF神经元也表现出目标位置依赖性的预期活动之前立即目标发病，这表明猴子预测块内的目标位置。这些结果表明，FEF神经元在短期记忆中保持空间信息，即使这些信息与任务表现无关。
Spatial attention is known to gate entry into visual short-term memory, and some evidence suggests that spatial signals may also play a role in binding features or protecting object representations during memory maintenance. To examine the persistence of spatial signals during object short-term memory, the activity of neurons in the Frontal Eye Field (FEF) of macaque monkeys was recorded during an object-based delayed match-to-sample (DMS) task. In this task monkeys were trained to remember an object image over a brief delay, irrespective of the locations of the sample or target presentation. FEF neurons exhibited visual, delay, and target period activity, including selectivity for sample location and target location. Delay period activity represented the sample location throughout the delay, despite the irrelevance of spatial information for successful task completion. Furthermore, neurons continued to encode sample position in a variant of the task in which the matching stimulus never appeared in their response field, confirming that FEF maintains sample location independent of subsequent behavioral relevance. FEF neurons also exhibited target-position-dependent anticipatory activity immediately prior to target onset, suggesting that monkeys predicted target position within blocks. These results show that FEF neurons maintain spatial information during short-term memory, even when that information is irrelevant for task performance.