Newly observed binding mode in pancreatic ribonuclease.
Newly observed binding mode in pancreatic ribonuclease.
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新观察到的胰腺核糖核酸酶的结合模式。
DOI：
10.1016/0022-2836(92)90589-c
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发表时间：
1992
影响因子：
5.6
通讯作者：
R. Palmer
中科院分区：
文献类型：
--
作者：
C. Aguilar;P. J. Thomas;A. Mills;D. Moss;R. Palmer
含有鸟嘌呤的二核苷酸，当被浸泡到牛胰腺核糖核酸酶的晶体中时，被发现以一种意想不到的方式结合，这与早期X射线衍射研究的解释非常不同。这一发现促使对该实验室的三个单核苷酸-核糖核酸酶复合体进行了重新检查，从而对涉及鸟嘌呤单核苷酸的复合体进行了重新解释。
Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a re-examination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide.