Effect of regular exercise on senile dementia patients
Effect of regular exercise on senile dementia patients
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DOI：
10.1055/s-2007-964853
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发表时间：
2008-06-01
影响因子：
2.5
通讯作者：
Kim, D. -J.
中科院分区：
文献类型：
--
作者：
Kwak, Y. -S.;Um, S. -Y.;Kim, D. -J.
全世界老年痴呆症的发病率相当高。运动调节大脑功能，但其机制尚不清楚。探讨规律运动对老年性痴呆患者认知功能和运动能力的影响。将30例女性老年痴呆患者随机分为两组：运动组（EG，n = 15）和对照组（CG，n = 15）。运动组完成常规运动计划，并在基线、6个月和12个月后评估其认知功能、日常生活活动能力和运动能力水平。受试者每天锻炼30 - 60分钟，每周2 - 3次，持续12个月。老年痴呆患者运动组的简易精神状态检查量表（MMSE）（术前14.53 ± 5.34，术后17.47 ± 6.90）和日常生活活动能力（ADL）（术前14.40 ± 5.32，术后17.53 ± 5.46）评分较对照组显著提高。运动能力，如心肺功能（术前：128.47 +/- 55.43，术后：184.40 +/- 41.16），肌肉力量（术前：10.07 +/- 3.61，术后：13.7 +/- 3.90），肌肉耐力（前：8.13 +/- 4.45，后：12.13 +/- 5.14），灵活性（-1.53 +/- 30，后：2.20 +/-0.70），平衡（前：1.73 +/-0.28，后：1.20 +/-0.77）和敏捷（前：21.80 +/- 3.24，后：10.87 +/- 2.99）也在锻炼组中增加。我们的研究结果表明，定期锻炼可以提高痴呆症患者的认知和功能活动评分，这表明老年痴呆症可以通过参加定期锻炼计划来改善。
Dementia population worldwide is considerable in elderly people. Exercise regulates the brain function, but the mechanism by which it does so is unknown. The effect of regular exercise on cognitive function and exercise capacity in senile dementia patients was investigated. Thirty female patients with senile dementia who participated in the study were divided into two groups: the exercise group (EG, n = 15) and the control group (CG, n = 15). The exercise group completed a regular exercise program, and their cognitive function, activities of daily living and exercise capacity levels were evaluated at baseline, 6 months and after 12 months. Subjects exercised 30 - 60 minutes per day, 2 - 3 times per week for 12 months. Mini-mental state examination (MMSE) (pre: 14.53 +/- 5.34, post: 17.47 +/- 6.90) and ADL (pre: 14.40 +/- 5.32, post: 17.53 +/- 5.46) scores were significantly enhanced in the exercise group with senile dementia, compared to those in the control group. Exercise capacities such as cardiopulmonary function (pre: 128.47 +/- 55.43, post: 184.40 +/- 41.16), muscle strength (pre: 10.07 +/- 3.61, post: 13.7 +/- 3.90), muscular endurance (pre: 8.13 +/- 4.45, post: 12.13 +/- 5.14), flexibility (-1.53 +/- 30, post: 2.20 +/-.70,balance (pre: 1.73 +/-.28, post: 1.20 +/-.77), and agility (pre: 21.80 +/- 3.24, post: 10.87 +/- 2.99) also increased in the exercise group. Our findings showed that regular exercise can enhance cognitive and functional activity scores in dementia patients, suggesting that senile dementia may improve by participating in a regular exercise program.