Imaging of a retinal pigment epithelium aperture using polarization-sensitive optical coherence tomography
Imaging of a retinal pigment epithelium aperture using polarization-sensitive optical coherence tomography
复制标题
DOI：
10.1007/s10384-020-00787-4
复制
发表时间：
2020-11-10
影响因子：
2.4
通讯作者：
Kato, Satoshi
中科院分区：
文献类型：
--
作者：
Obata, Ryo;Yoshinaga, Akie;Kato, Satoshi
目的应用偏振敏感光学相干断层扫描（PS-OCT）评价视网膜色素上皮（RPE）裂孔的情况。研究设计回顾性连续病例系列。方法回顾性研究包括在东京大学医院黄斑诊所评估的三只眼（三名患者）患有RPE孔径和年龄相关性黄斑变性（AMD）。一个三维数据集的去极化信息与PS-OCT的临床原型获得。用PS-OCT将RPE孔识别为色素上皮脱离（PED）的RPE层中的去极化的不连续性。在孔径周围也观察到RPE层中去极化的不均匀降低。在孔上方观察到两种结果，视网膜内局灶区具有高反射率和增加的去偏振，视网膜下带具有中等反射率和低去偏振。在25个点上根据眼底微视野测量的视网膜敏感度与相应区域的去极化程度显著相关（r平方= 0.60，p = 0.0001）。结论视网膜色素上皮孔呈圆形去极化不连续。PS-OCT的结果表明PED的上覆RPE发生萎缩性变化。去极化程度与视网膜敏感度有关。目前的结果表明，RPE孔内的萎缩性AMD的频谱开发。
Purpose To evaluate cases with a retinal pigment epithelium (RPE) aperture using polarization-sensitive optical coherence tomography (PS-OCT). Study design Retrospective consecutive case series. Methods A retrospective study that included three eyes (three patients) with RPE aperture and age-related macular degeneration (AMD) evaluated at the Macular Clinic in Tokyo University Hospital. A three-dimensional dataset of depolarization information was obtained with a clinical prototype of PS-OCT. Results All patients were categorized as intermediate AMD. RPE apertures were identified with PS-OCT as discontinuities of depolarization in the RPE layer of the pigment epithelial detachment (PED). A nonuniform decrease of depolarization in the RPE layer was also observed around the aperture. Two findings were observed above the aperture, intraretinal focal areas with high reflectivity and increased depolarization and subretinal bands with moderate reflectivity and low depolarization. Retinal sensitivity according to fundus microperimetry measured at 25 points was significantly associated with the degree of depolarization at the corresponding area (r-square = 0.60, p = 0.0001). Conclusion The RPE aperture was characterized as a round discontinuity of depolarization. The findings with PS-OCT suggest atrophic changes in the overlying RPE of the PED. The degree of depolarization was associated with retinal sensitivity. The current results indicate that RPE apertures developed within the spectrum of atrophic AMD.