Klotho, stem cells, and aging.
Klotho, stem cells, and aging.
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DOI：
10.2147/cia.s84978
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发表时间：
2015
影响因子：
3.6
通讯作者：
Hu MC
中科院分区：
文献类型：
--
作者：
Bian A;Neyra JA;Zhan M;Hu MC
衰老是一个不可避免的渐进的生物过程，涉及到功能障碍，并最终破坏每一个组织和器官。这一过程是由遗传因素和后天因素之间严格监管和复杂的相互作用推动的。Klotho是一种编码单通路跨膜蛋白Klotho的抗衰老基因，它通过多种机制发挥衰老抑制作用，如抗氧化、抗衰老、抗自噬以及调节许多信号通路，包括胰岛素样生长因子和Wnt。Klotho缺乏会激活Wnt的表达和活性，从而导致干细胞的衰老和枯竭，从而引发组织萎缩和纤维化。相比之下，Klotho蛋白被证明可以抑制Wnt信号转导，抑制细胞衰老和保存干细胞。更好地了解Klotho对干细胞的潜在影响可以为Klotho缺乏症相关衰老和疾病的细胞和分子机制提供新的见解。Klotho蛋白可能是一种很有前途的衰老和衰老相关疾病的治疗剂。
Aging is an inevitable and progressive biological process involving dysfunction and eventually destruction of every tissue and organ. This process is driven by a tightly regulated and complex interplay between genetic and acquired factors. Klotho is an antiaging gene encoding a single-pass transmembrane protein, klotho, which serves as an aging suppressor through a wide variety of mechanisms, such as antioxidation, antisenescence, antiautophagy, and modulation of many signaling pathways, including insulin-like growth factor and Wnt. Klotho deficiency activates Wnt expression and activity contributing to senescence and depletion of stem cells, which consequently triggers tissue atrophy and fibrosis. In contrast, the klotho protein was shown to suppress Wnt-signaling transduction, and inhibit cell senescence and preserve stem cells. A better understanding of the potential effects of klotho on stem cells could offer novel insights into the cellular and molecular mechanisms of klotho deficiency-related aging and disease. The klotho protein may be a promising therapeutic agent for aging and aging-related disorders.