Inhibitory and Bactericidal Activities of Daptomycin, Vancomycin, and Teicoplanin against Methicillin-Resistant Staphylococcus aureus Isolates Collected from 1985 to 2007
Inhibitory and Bactericidal Activities of Daptomycin, Vancomycin, and Teicoplanin against Methicillin-Resistant Staphylococcus aureus Isolates Collected from 1985 to 2007
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DOI：
10.1128/aac.01022-08
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发表时间：
2009-05-01
影响因子：
4.9
通讯作者：
Brown, Steven D.
中科院分区：
文献类型：
--
作者：
Traczewski, Maria M.;Katz, Bradley D.;Brown, Steven D.
研究了达托霉素、万古霉素和替考拉宁对479株耐甲氧西林金黄色葡萄球菌的抑菌和杀菌活性。这些分离株是从1985年至2007年从美国和欧洲的医院收集的，主要来自血液和脓肿培养。测定三种药物的最低抑菌浓度(MIC)和最低杀菌浓度(MBCs)，并计算MBC/MIC比值以确定是否存在耐药。容差被定义为当MBC大于或等于电阻的断点时，MBC/MIC比率为32或MBC/MIC比率为16。对万古霉素和替考拉宁耐药率分别为6.1%和18.8%。未观察到对达托霉素的耐受性。
The inhibitory and bactericidal activities of daptomycin, vancomycin, and teicoplanin against a collection of 479 methicillin-resistant Staphylococcus aureus isolates were assessed. The isolates were collected from U. S. and European hospitals from 1985 to 2007 and were primarily from blood and abscess cultures. The MICs and minimum bactericidal concentrations (MBCs) of the three agents were determined, and the MBC/MIC ratios were calculated to determine the presence or absence of tolerance. Tolerance was defined as an MBC/MIC ratio of >= 32 or an MBC/MIC ratio of >= 16 when the MBC was greater than or equal to the breakpoint for resistance. Tolerance to vancomycin and teicoplanin was observed in 6.1% and 18.8% of the strains, respectively. Tolerance to daptomycin was not observed.