Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection
Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection
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DOI：
10.1097/mco.0b013e32802b7030
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发表时间：
2007-03-01
影响因子：
3.1
通讯作者：
Bazan, Nicolas G.
中科院分区：
文献类型：
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作者：
Bazan, Nicolas G.
综述的目的为了总结最近的研究结果，二十二碳六烯酸（DHA）是具有抗炎和细胞保护特性的立体特异性衍生物的前体。最近的研究结果二十二碳六烯酸衍生的介质神经保护素D1在视网膜色素上皮细胞中形成时，面对氧化应激，在脑中实验性中风，在阿尔茨海默氏病患者的人脑以及培养的人脑细胞中。Neuroprotectin D1显示有效的抗炎和神经保护biological.Summary在这里，我们总结了最近的研究表明，在脑缺血再灌注和视网膜色素上皮细胞暴露于氧化应激立体特异性docosahexaenoate氧化途径被激活，并导致形成的docosanoid信使。确定了两种二十二碳六烯酸-氧化途径：第一种负责信使神经保护素D1的形成，第二种途径在阿司匹林存在下活跃，导致消退素型介质（17 R-DHA）的形成。神经保护素D1诱导抗凋亡、抗炎信号传导，具有神经保护作用。
Purpose of review To summarize recent findings that docosahexaenoate (DHA) is the precursor of stereospecific derivatives with anti-inflammatory and cytoprotective properties.Recent findings The docosahexaenoate-derived mediator neuroprotectin D1 is formed in retinal pigment epithelial cells when confronted with oxidative stress, in the brain during experimental stroke, and in the human brain from Alzheimer's disease patients as well as in human brain cells in culture. Neuroprotectin D1 displays potent anti-inflammatory and neuroprotective bioactivity.Summary Here, we summarize recent studies demonstrating that in brain ischemia-reperfusion and in retinal pigment epithelial cells exposed to oxidative stress stereospecific docosahexaenoate-oxygenation pathways are activated and lead to the formation of docosanoid messengers. Two docosahexaenoate-oxygenation pathways were identified: the first is responsible for the formation of the messenger neuroprotectin D1 and the second pathway, which is active in the presence of aspirin, leads to the formation of the resolvin-type mediators (17R-DHA). Neuroprotectin D1 induces antiapoptotic, anti-inflammatory signaling and is neuroprotective.