Quantitative studies of microcirculatory structure and function. III. Microvascular hemodynamics of cat mesentery and rabbit omentum.
Quantitative studies of microcirculatory structure and function. III. Microvascular hemodynamics of cat mesentery and rabbit omentum.
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DOI：
10.1161/01.res.41.3.380
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发表时间：
1977-09
影响因子：
20.1
通讯作者：
B. Zweifach;H. Lipowsky
中科院分区：
文献类型：
--
作者：
B. Zweifach;H. Lipowsky
我们同时测量了血管内压力和红细胞速度的血管，使模块化配置的微血管网在肠系膜和网膜。这些变量的分析和计算的体积流速的小动脉，其中有一个最大直径为56微米，通过“真正的毛细血管”（通常为7微米的肠系膜和8微米的网膜）到56微米的小静脉。压力和流量的空间变化与每个管网的地形特征有关。提供了每个网络的血管化统计数据，并证明了潜在微血管交换面积与模块平面面积的独特比率，网膜的值为0.71 +/- 0.22（SD），肠系膜的值为0.19“/- 0.03（SD）。对每个模块的体积流速的分析表明，与每个模块化网络所服务的组织的平面面积呈线性关系。网膜和肠系膜的原位灌注速率分别为1180 ml/min/100 g和105 ml/min/100 g。评价了网膜和肠系膜回路的血流动力学阻力，在网膜的情况下，发现其与模块的平面面积成反比。描述了网膜和肠系膜中连续模块的马赛克的压力和流量的动脉到静脉分布，并且与每个网络的并行和串行微血管的部署相关。
We made simultaneous measurements of intravascular pressure and red blood cell velocity for vessels which make up the modular configuration of microvascular networks in mesentery and omentum. An analysis of these variables and the computed volumetric flow rates is presented for arterioles which had a maximum diameter of 56 micrometer through the "true capillaries" (typically 7 micrometer for mesentery and 8 micrometer for omentum) to 56-micrometer venules. The spatial variance of pressure and flow is related to topographical features of each network. Vascularization statistics for each network are presented and demonstrate a unique ratio of potential microvascular exchange area to module planar area, with values of 0.71 +/- 0.22 (SD) for omentum and 0.19 "/- 0.03 (SD) for mesentery. Analysis of the volumetric flow rate for each module demonstrates a linear relationship to the planar area of tissue serviced by each modular network. In situ perfusion rates of 1180 ml/min per 100 g and 105 ml/min per 100 g were determined for omentum and mesentery, respectively. The hemodynamic resistance of the omental and mesenteric circuitry was evaluated, and in the case of the omentum, found to be inversely proportional to the planar area of the module. The arterial to venous distribution of pressure and flow for the mosaic of contiguous modules in omentum and mesentery is described and related to the deployment of parallel and serial microvessels of each network.