Hyperplasia to Neoplasia Sequence of Duodenal and Pancreatic Neuroendocrine Diseases and Pseudohyperplasia of the PP-cells in the Pancreas
Hyperplasia to Neoplasia Sequence of Duodenal and Pancreatic Neuroendocrine Diseases and Pseudohyperplasia of the PP-cells in the Pancreas
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DOI：
10.1007/s12022-014-9317-8
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发表时间：
2014-06-01
影响因子：
4.4
通讯作者：
Sipos, Bence
中科院分区：
文献类型：
--
作者：
Kloeppel, Gunter;Anlauf, Martin;Sipos, Bence
神经内分泌细胞系统的增生性改变可能有演变成肿瘤性疾病的潜力。在遗传决定和遗传性神经内分泌肿瘤综合征（如MEN 1）的情况下尤其如此。综述讨论了MEN 1相关的增生-瘤形成序列在十二指肠胃泌素瘤和胰腺胰高血糖素生成肿瘤的发展。它还介绍了其他新描述的疾病（例如，胰高血糖素细胞腺瘤病和胰岛素瘤病），其中肿瘤（或最可能）也在胰岛细胞增生之前。最后，胰头富含PP的胰岛的假性增生被定义为明显不同于其他增生性肿瘤性神经内分泌疾病的生理状态。
Hyperplastic changes of the neuroendocrine cell system may have the potential to evolve into neoplastic diseases. This is particularly the case in the setting of genetically determined and hereditary neuroendocrine tumor syndromes such as MEN1. The review discusses the MEN1-associated hyperplasia-neoplasia sequence in the development of gastrinomas in the duodenum and glucagon-producing tumors in the pancreas. It also presents other newly described diseases (e.g., glucagon cell adenomatosis and insulinomatosis) in which the tumors are (or most likely) also preceded by islet cell hyperplasia. Finally, the pseudohyperplasia of PP-rich islets in the pancreatic head is defined as a physiologic condition clearly differing from other hyperplastic-neoplastic neuroendocrine diseases.