Dickkopf-1 expression is a novel prognostic marker for gastric cancer.
Dickkopf-1 expression is a novel prognostic marker for gastric cancer.
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DOI：
10.1155/2012/804592
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发表时间：
2012
影响因子：
--
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Gao C;Xie R;Ren C;Yang X
瞄准目的探讨Dickkopf-1在胃癌中的表达及意义。方法.采用实时定量逆转录聚合酶链反应（qRT-PCR）和免疫组化方法检测胃癌患者原发癌组织及癌旁组织中Dickkopf-1 mRNA和蛋白的表达。结果Dickkopf-1 mRNA和蛋白在胃癌组织中的表达均显著高于癌旁组织。其阳性表达与肿瘤浸润深度、脉管浸润、淋巴结转移、远处转移及TNM分期有关。此外，在I、II和III期胃癌中，Dickkopf-1高表达患者的5年生存率显著低于低表达患者。在IV期，Dickkopf-1表达与5年生存率无关。多因素分析提示Dickkopf-1表达上调是胃癌的独立预后指标。结论一组胃癌病例显示Dickkopf-1表达上调，这与进行性病理特征和侵袭性临床病程相关。因此，Dickkopf-1表达可能是胃癌患者预后不良的预测因子。这是第一个报告描述Dickkopf-1参与胃癌。
Aim. To investigate the involvement of Dickkopf-1 expression in gastric cancer. Methods. Dickkopf-1 mRNA and protein expression were determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry in specimens of primary cancer and their adjacent noncancerous tissues in gastric cancer patients. Results. Dickkopf-1 mRNA and protein expression levels were both significantly upregulated in gastric cancer lesions compared with adjacent noncancerous tissues. Its positive expression was correlated with depth of invasion, vessel invasion, lymph node and distant metastasis, and TNM stage of tumors. Additionally, in stages I, II, and III gastric cancers, the 5- year survival rate of patients with a high expression of Dickkopf-1 was significantly lower than that in patients with low expression. In stage IV, Dickkopf-1 expression did not correlate with the 5-year survival rate. Further multivariate analysis suggested that the up-regulation of Dickkopf-1 was an independent prognostic indicator for gastric cancer. Conclusion. A subset of cases with gastric cancer revealed the up-regulation of Dickkopf-1, which was associated with a progressive pathological feature and an aggressive clinical course. Therefore, Dickkopf-1 expression may be predictor for poor prognosis in patients with gastric cancer. This is the first report describing the involvement of Dickkopf-1 in gastric cancer.
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影响因子：
11.2
作者：
Yamabuki, Takumi;Takano, Atsushi;Daigo, Yataro
通讯作者：
Daigo, Yataro
DOI：
10.1016/j.bbrc.2006.11.079
发表时间：
2007-01-19
影响因子：
3.1
作者：
Mikheev, Andrei M.;Mikheeva, Svetlana A.;Zarbl, Helmut
通讯作者：
Zarbl, Helmut
影响因子：
5
作者：
Wirths, O;Waha, A;Pietsch, T
通讯作者：
Pietsch, T
肺癌患者血清Dickkopf-1浓度的临床意义和预后价值
影响因子：
9.3
作者：
Sheng, Shi Le;Huang, Gang;Qin, Wen Xin
通讯作者：
Qin, Wen Xin
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影响因子：
--
作者：
Tseng CW;Lin CC;Chen CN;Huang HC;Juan HF
通讯作者：
Juan HF