Memory CD8+ T cell differentiation:: initial antigen encounter triggers a developmental program in naive cells
Memory CD8+ T cell differentiation:: initial antigen encounter triggers a developmental program in naive cells
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DOI：
10.1038/87720
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发表时间：
2001-05-01
影响因子：
30.5
通讯作者：
Ahmed, R
中科院分区：
文献类型：
--
作者：
Kaech, SM;Ahmed, R
记忆性T细胞分化的规则还不清楚。这项研究表明，在抗原刺激后，初始CD8（+）T细胞至少分裂7次，并分化为效应细胞和记忆细胞。一旦亲本幼稚CD8（+）T细胞被激活，这种发育过程就不能被中断，并且子细胞在没有进一步抗原刺激的情况下继续分裂和分化。这些数据表明，最初的抗原接触触发了一个指导性的发育程序，不需要进一步的抗原刺激，并没有停止，直到记忆CD8（+）T细胞的形成。
The rules that govern memory T cell differentiation are not well understood. This study shows that after antigenic stimulation naive CD8(+)T cells become committed to dividing at least seven times and differentiating into effector and memory cells. Once the parental naive CD8(+) T cell had been activated, this developmental process could not be interrupted and the daughter cells continued to divide and differentiate in the absence of further antigenic stimulation. These data indicate that initial antigen encounter triggers an instructive developmental program that does not require further antigenic stimulation and does not cease until memory CD8(+) T cell formation.