PROTON MR SPECTROSCOPY OF THE BRAIN IN AIDS DEMENTIA COMPLEX
PROTON MR SPECTROSCOPY OF THE BRAIN IN AIDS DEMENTIA COMPLEX
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DOI：
10.1097/00004728-199207000-00007
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发表时间：
1992-07-01
影响因子：
1.3
通讯作者：
HARRIS, JRW
中科院分区：
文献类型：
--
作者：
MENON, DK;AINSWORTH, JG;HARRIS, JRW
对8名健康志愿者和11名人类免疫缺陷病毒感染和不同阶段的艾滋病痴呆综合征（ADC）患者进行了脑部质子MR波谱分析。无ADC或早期ADC患者的频谱表现与正常志愿者无显著差异。中重度ADC患者的光谱显示N-乙酰天冬氨酸（NAA）水平相对于肌酸（Cr）显著降低，并且还显示含胆碱化合物（相对于Cr）升高。因为NAA被认为是正常功能神经元的代谢标志物，这些发现表明在中度至重度ADC中存在神经元损伤或损失。这些发现的意义进行了讨论。
Proton MR spectroscopy of the brain has been undertaken in 8 healthy volunteers and in 11 patients with human immunodeficiency virus infection and varying stages of AIDS dementia complex (ADC). Spectral appearances in patients with no ADC or early ADC were not significantly different from normal volunteers. Spectra from patients with moderate to severe ADC exhibited significant reductions in levels of N-acetyl aspartate (NAA) relative to creatine (Cr) and also showed elevations in choline containing compounds (relative to Cr). Because NAA is thought to be a metabolic marker for normally functioning neurons, these findings suggest the presence of neuronal injury or loss in moderate to severe ADC. The significance of these findings is discussed.