The mechanism of hedgehog signal transduction
The mechanism of hedgehog signal transduction
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DOI：
10.1042/bst0331509
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发表时间：
2005-12-01
影响因子：
3.9
通讯作者：
Kalderon, D
中科院分区：
文献类型：
--
作者：
Kalderon, D
Hedgehog（Hh）蛋白是少数分泌信号蛋白家族之一，其负责许多动物发育期间的细胞相互作用。因此，Hh信号在不同的时间和不同的细胞中产生许多不同的反应。至于其他多功能配体，这需要调节表达模式，细胞间配体运动和配体破坏的特殊机制，以及将通用信号状态（开或关）与响应细胞的状态整合以产生适当的细胞特异性响应的机制。在这里，我讨论什么是已知的生化机制，Hh信号转导，以改变基因转录的模式。
Hedgehog (Hh) proteins are one of a small number of families of secreted signalling proteins that are responsible for cell interactions during development in many animals. As such, Hh signals produce many different responses at different times and in different cells. As for other multifunctional ligands, this requires regulated patterns of expression, special mechanisms for ligand movement between cells and ligand destruction, and mechanisms for integrating a generic signalling state (on or off) with the status of responding cells in order to produce an appropriate cell-specific response. Here I discuss what is known about the biochemical mechanisms by which an Hh signal is transduced in order to change the patterns of gene transcription.