Cutaneous Squamous Cell Carcinoma Arising in Immunosuppressed Patients: A Systematic Review of Tumor Profiling Studies.
Cutaneous Squamous Cell Carcinoma Arising in Immunosuppressed Patients: A Systematic Review of Tumor Profiling Studies.
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DOI：
10.1016/j.xjidi.2022.100126
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发表时间：
2022-07
期刊：
影响因子：
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通讯作者：
Whitley, Melodi Javid
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文献类型：
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作者：
Blue, Elliot D;Freeman, S Caleb;Lobl, Marissa B;Clarey, Dillon D;Fredrick, Rose L;Wysong, Ashley;Whitley, Melodi Javid
随着实体器官移植变得越来越普遍，越来越多的人作为免疫抑制人群的成员生活，皮肤鳞状细胞癌（cSCC）的风险升高。虽然在了解cSCC的发病机制方面取得了很大进展，但对免疫抑制患者和器官移植受者中肿瘤发生的驱动因素知之甚少。这项系统性综述旨在综合有关遗传和表观遗传改变以及蛋白质和mRNA表达变化的信息，这些变化使这一不断增长的人群面临cSCC的风险，影响治疗反应，并促进肿瘤侵袭性。该综述将为研究者提供一个框架，以确定未来的研究领域，并为临床医生提供如何最好地管理这些患者的额外见解。
As solid organ transplantation becomes more prevalent, more individuals are living as members of the immunosuppressed population with an elevated risk for cutaneous squamous cell carcinoma (cSCC). Although great progress has been made in understanding the pathogenesis of cSCC in general, little is known about the drivers of tumorigenesis in immunosuppressed patients and organ-transplant recipients, specifically. This systematic review sought to synthesize information regarding the genetic and epigenetic alterations as well as changes in protein and mRNA expression that place this growing population at risk for cSCC, influence treatment response, and promote tumor aggressiveness. This review will provide investigators with a framework to identify future areas of investigation and clinicians with additional insight into how to best manage these patients.