Premature birth impacts bolus size and shape through nursing in infant pigs.
Premature birth impacts bolus size and shape through nursing in infant pigs.
复制标题
早产会通过哺乳影响小猪的食团大小和形状。
DOI：
10.1038/s41390-019-0624-0
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发表时间：
2020
影响因子：
3.6
通讯作者：
Gould,FrancoisDH
中科院分区：
文献类型：
--
作者：
Mayerl,ChristopherJ;Myrla,AlexisM;Bond,LauraE;Stricklen,BethanyM;German,RebeccaZ;Gould,FrancoisDH
背景食物团的形成对于正确的进食功能是至关重要的，并且在吞咽之前食物团的大小和形状存在实质性变化。早产儿表现出获取和加工食物的能力下降，但这与他们的食团大小和形状有何关系尚不清楚。在这里，我们测试两个假设：（1），团的大小和形状将不同之间的条款和早产儿，和（2）团的大小和形状将通过在长期和早产infants.MethodsTo测试这些假设的发展纵向变化，我们测量团的大小和形状在早产和长期的婴儿猪纵向通过护理使用高速videofluorescence.ResultsPreterm婴儿猪吞下较小体积的牛奶。虽然足月儿随着年龄的增长，每次吞咽的牛奶量会增加，但早产儿不会。这些变化在丸量也与丸形状的变化;较大的丸变得更长，因为他们更好地填补了可用的解剖空间的valleculae.ConclusionsThese结果表明，早产降低了早产猪的能力，增加丸的大小，因为他们的成长，影响在这个脆弱的人口发展。这些结果强调，对足月儿喂养的研究可能无法转化为早产儿。
BackgroundThe formation of a bolus of food is critical for proper feeding function, and there is substantial variation in the size and shape of a bolus prior to a swallow. Preterm infants exhibit decreased abilities to acquire and process food, but how that relates to their bolus size and shape is unknown. Here, we test two hypotheses: (1) that bolus size and shape will differ between term and preterm infants, and (2) bolus size and shape will change longitudinally through development in both term and preterm infants.MethodsTo test these hypotheses, we measured bolus size and shape in preterm and term infant pigs longitudinally through nursing using high-speed videofluoroscopy.ResultsPreterm infant pigs swallowed smaller volumes of milk. Although term infants increased the amount of milk per swallow as they aged, preterm infants did not. These changes in bolus volume were also correlated with changes in bolus shape; larger boluses became more elongate as they better filled the available anatomical space of the valleculae.ConclusionsThese results suggest that preterm birth reduces the ability of preterm pigs to increase bolus size as they grow, affecting development in this fragile population. These results highlight that studies on term infant feeding may not translate to preterm infants.