Who gets genomic testing for breast cancer recurrence risk?
Who gets genomic testing for breast cancer recurrence risk?
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DOI：
10.1159/000353518
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发表时间：
2013
影响因子：
1.7
通讯作者：
Brewer NT
中科院分区：
文献类型：
--
作者：
DeFrank JT;Salz T;Reeder-Hayes K;Brewer NT
我们的研究检查了患者的特征，信仰和决策风格是否与乳腺癌复发风险的基因组检测相关。参与者是132名符合Oncotype DX基因组检测条件的早期乳腺癌患者。我们在2009-2010年采访了患者，并从医疗图表中获得了信息。有一半的女性有资格接受乳腺癌复发风险基因组检测，而最常见的原因是女性医生不提供检测（80%）。与未接受测试的女性相比，测试接受者更有可能不确定是否接受化疗治疗（p<0.05）。接受该测试的女性具有较低的晚期疾病病理学，回忆客观复发风险较低，感知复发风险较低，并且略年轻（所有p<0.05）。大多数将自己的决策风格描述为主动的女性接受了测试（75%），而将自己的决策风格描述为被动的女性很少接受测试（12%）（p<0.01）。在我们研究的大学诊所中，基因组检测在可能从结果提供的信息中获益最多的患者中似乎更常见，但需要在更大规模的研究中进行确认。
Our study examined whether patient characteristics, beliefs, and decision-making styles were associated with uptake of genomic testing for breast cancer recurrence risk. Participants were 132 early-stage breast cancer patients eligible for the Oncotype DX genomic test. We interviewed patients in 2009–2010 and obtained information from medical charts. Half of women eligible for genomic testing for breast cancer recurrence risk received it. The most common reason for not getting the test was that women’s physicians did not offer it (80%). Test recipients were more likely to be unsure about receiving chemotherapy treatment compared to women who did not receive the test (p<.05). Women who received the test had less advanced disease pathologies, recalled a lower objective recurrence risk, perceived lower recurrence risk and were slightly younger (all p<.05). Most women who described their decision-making style as active received the test (75%) whereas few women who described their style as passive received the test (12%) (p<.01). In the university clinic we studied, genomic testing appeared to more common among patients who may benefit most from the information provided by results, but confirmation in larger studies is needed.
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