A technological update of molecular diagnostics for infectious diseases.
A technological update of molecular diagnostics for infectious diseases.
复制标题
传染病分子诊断的技术更新。
DOI：
10.2174/1871526510808030183
复制
发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Liu YT
中科院分区：
文献类型：
--
作者：
Liu YT
鉴定致病病原体对于大多数传染病的治疗选择至关重要。在过去的十年中，已经开发了许多FDA批准的分子测定;与传统测试相比，通常更敏感和特异。由于人类基因组测序计划的技术发展，出现了高通量和多重测定的新趋势。综述了微阵列和超高通量测序技术在微生物学诊断中的应用。到2014年，1000美元基因组技术的竞争将在不久的将来对传染病的诊断和治疗产生深远的影响。
Identification of a causative pathogen is essential for the choice of treatment for most infectious diseases. Many FDA approved molecular assays; usually more sensitive and specific compared to traditional tests, have been developed in the last decade. A new trend of high throughput and multiplexing assays are emerging thanks to technological developments for the human genome sequencing project. The applications of microarray and ultra high throughput sequencing technologies for diagnostic microbiology are reviewed. The race for the $1000 genome technology by 2014 will have a profound impact in diagnosis and treatment of infectious diseases in the near future.