Ro/SS-A antigen in human platelets. Different distributions of the isoforms of Ro/SS-A protein and the Ro/SS-A-binding RNA.
Ro/SS-A antigen in human platelets. Different distributions of the isoforms of Ro/SS-A protein and the Ro/SS-A-binding RNA.
复制标题
人血小板中的 Ro/SS-A 抗原。
DOI：
10.1002/art.1780340715
复制
发表时间：
1991
影响因子：
--
通讯作者：
Reichlin,M
中科院分区：
文献类型：
--
作者：
Itoh,Y;Reichlin,M
RO/SS-A抗原存在于人的血小板中，其浓度约为淋巴细胞的二十分之一到三十分之一，但Ro/SS-A亚型的分布与淋巴细胞或红细胞中的分布不同。血小板中的Ro/SS-A主要是52kd形式。此外，血小板中的52-kd亚型与淋巴细胞中的52-kd亚型在抗原性上不同。除了不同的亚型分布外，在血小板中还发现了不同分布的Ro/SS-A结合RNA(Hy RNA)。在淋巴细胞和其他有核细胞中存在4种Hy RNA(hY1、hY3、hY4和hY5)，但我们发现血小板只含有2种Hy RNA：hY3和hY4。这种Hy RNA的分布也不同于红细胞中只含有hY1和hY4的分布。Ro/SS-A组分在淋巴细胞、红细胞和血小板中的不同分布提示了不同蛋白质和RNA组分的不同功能，以及与Ro/SS-A-Autoanti-Ro/SS-A系统相关的不同组织特异性事件的可能性。
Ro/SS‐A antigen is present in human platelets at a concentration that is approximately one‐twentieth to one‐thirtieth its concentration in lymphocytes, but the distribution of the Ro/SS‐A isoforms is different from that in lymphocytes or red blood cells. The Ro/SS‐A in platelets is largely the 52‐kd form. Moreover, the 52‐kd isoform in platelets is antigenically different from that in lymphocytes. In addition to the varied isoform distribution, a different distribution of the Ro/SS‐A–binding RNA (hY RNA) is seen in platelets. While there are 4 hY RNA (hY1, hY3, hY4, and hY5) in lymphocytes and other nucleated cells, we have found that platelets contain only 2 hY RNA: hY3 and hY4. This hY RNA distribution is also different from that in red blood cells, which contain only hY1 and hY4. The different distributions of the Ro/SS‐A components in lymphocytes, red blood cells, and platelets suggest different functional roles for the various protein and RNA components, as well as the possibility of different tissue‐specific events related to the Ro/SS‐A–autoanti–Ro/SS‐A system.