Self-assembled virus-like particles with magnetic cores
Self-assembled virus-like particles with magnetic cores
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DOI：
10.1021/nl071083l
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发表时间：
2007-08-01
期刊：
影响因子：
10.8
通讯作者：
Dragnea, Bogdan
中科院分区：
文献类型：
--
作者：
Huang, Xinlei;Bronstein, Lyudmila M.;Dragnea, Bogdan
研究发现，即使纳米颗粒大于天然衣壳的内腔，功能化球形纳米颗粒也能被病毒蛋白笼有效地封装。这一结果提出了重新编程病毒结构蛋白自组装的有趣可能性。在这项工作中使用的氧化铁纳米模板是超顺磁性的，阻断温度约为250 K，使得这些病毒样颗粒在磁共振成像和生物磁性材料等应用中很有趣。本研究中描述的类病毒颗粒组装的另一个新特征是使用阴离子脂质胶束涂层代替与无机纳米模板共价结合的分子层。讨论了两种功能化策略之间的差异。
Efficient encapsulation of functionalized spherical nanoparticles by viral protein cages was found to occur even if the nanoparticle is larger than the inner cavity of the native capsid. This result raises the intriguing possibility of reprogramming the self-assembly of viral structural proteins. The iron oxide nanotemplates used in this work are superparamagnetic, with a blocking temperature of about 250 K, making these virus-like particles interesting for applications such as magnetic resonance imaging and biomagnetic materials. Another novel feature of the virus-like particle assembly described in this work is the use of an anionic lipid micelle coat instead of a molecular layer covalently bound to the inorganic nanotemplate. Differences between the two functionalization strategies are discussed.