Synthesis and Insecticidal Activities of Novel Spin-Labeled Derivatives of Camptothecin
Synthesis and Insecticidal Activities of Novel Spin-Labeled Derivatives of Camptothecin
复制标题
新型喜树碱自旋标记衍生物的合成及杀虫活性
DOI：
10.1002/hc.20734
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发表时间：
2011-01-01
影响因子：
0.3
通讯作者：
Li, Hong-Yu
中科院分区：
文献类型：
--
作者：
Liu, Ying-Qian;Dai, Wei;Li, Hong-Yu
我们继续寻找用于防治椰心叶甲幼虫的天然产物基化合物，首先测试了8种自旋标记的喜树碱衍生物7a-h和中间体2对椰心叶甲5龄幼虫的杀虫活性。其中化合物7a和2对B 5龄幼虫的校正死亡率分别为69.55%和74.07%。longissima，分别。这些化合物的不同杀虫活性范围表明，这些化合物中L-氨基酸结构的变化显著影响了该类化合物的活性谱，并从中揭示了一些重要的SAR信息。Heteroatom Chem 22：687-691，2011;在wileyonlinelibrary.com在线查看这篇文章。DOI 10.1002/hc.20734
Continuing our search for natural product based compounds for the control of Brontispa longissima larvae, eight spin-labeled camptothecin derivatives 7a-h and the intermediate 2 were first tested for their insecticidal activities against fifth-instar larvae of Brontispa longissima. Among all the tested compounds, especially compounds 7a and 2 showed promising insecticidal activities with the corrected mortality rates of 69.55% and 74.07% against fifth-instar larvae of B. longissima, respectively. The different insecticidal activity ranges of these compounds indicated that the variation of the structures of L-amino acids in these compounds markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it. (C) 2011 Wiley Periodicals, Inc. Heteroatom Chem 22: 687-691, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20734