MECHANISM FOR BONE DISEASE FOUND IN INHABITANTS ENVIRONMENTALLY EXPOSED TO CADMIUM DECREASED SERUM 1-ALPHA 25 DIHYDROXYVITAMIN D LEVEL
MECHANISM FOR BONE DISEASE FOUND IN INHABITANTS ENVIRONMENTALLY EXPOSED TO CADMIUM DECREASED SERUM 1-ALPHA 25 DIHYDROXYVITAMIN D LEVEL
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DOI：
10.1007/bf00377675
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发表时间：
1987-01-01
影响因子：
3
通讯作者：
ISHIZAKI M
中科院分区：
文献类型：
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作者：
NOGAWA K;TSURITANI I;ISHIZAKI M
为了研究由暴露于镉引起的骨病的机制，从5名itai-itai病患者、36名具有肾小管损伤的Cd暴露居民和17名非暴露个体收集血清样品，并分析1 α，25-二羟维生素D [1 α，25（OH）2D]、甲状旁腺激素、β 2-微球蛋白、钙和无机磷。肾小管磷酸盐重吸收百分比（%TRP）的测量仅在镉暴露受试者上进行。血清1 α，25（OH）2D水平低于itai-itai病患者和镉暴露受试者的肾损害比非暴露受试者。血清中的甲状旁腺激素和β 2-微球蛋白浓度在镉暴露的受试者中较高。血清1 α降低，25（OH）2D水平与甲状旁腺激素、β 2-微球蛋白和%TRP的血清浓度密切相关。本研究表明，镉引起的骨效应主要是由于维生素D和甲状旁腺激素代谢紊乱，这是由镉引起的肾脏损害。
To investigate the mechanism for bone disease caused by exposure to cadmium serum samples were collected from 5 itai-itai disease patients, 36 Cd-exposed residents with renal tubular damage and 17 non-exposed individuals and analyzed for 1.alpha.,25-dihydroxyvitamin D [1.alpha.,25(OH)2D], parathyroid hormone, .beta.2-microglobulin, calcium and inorganic phosphorus. Measurement of percentage tubular reabsorption of phosphate (%TRP) were performed only on the Cd-exposed subjects. Serum 1.alpha.,25(OH)2D levels were lower in itai-itai disease patients and cadmium-exposed subjects with renal damage than in non-exposed subjects. Parathyroid hormone and .beta.2-microglobulin concentrations in serum were higher in the Cd-exposed subjects. Decrease in serum 1.alpha.,25(OH2D levels were closely related to serum concentrations of parathyroid hormone, .beta.2-microglobulin and %TRP. This study suggests that cadmium-induced bone effects were mainly due to a disturbance in vitamin D and parathyroid hormone metabolism, which was caused by the cadmium-induced kidney damage.