The Potential Uses of N-acetylcysteine in Dermatology: A Review.
The Potential Uses of N-acetylcysteine in Dermatology: A Review.
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发表时间：
2019-05
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通讯作者：
M. Janeczek;L. Moy;A. Riopelle;Olivia Vetter;J. Reserva;R. Tung;J. Swan
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作者：
M. Janeczek;L. Moy;A. Riopelle;Olivia Vetter;J. Reserva;R. Tung;J. Swan
背景：在最近的研究中，N-乙酰半胱氨酸已被证明在几种皮肤病中有效。目的：目的是审查评估N-乙酰半胱氨酸在皮肤疾病中的疗效的临床试验。设计：检索PubMed数据库，并手动检索参考文献中的临床试验。研究包括1966年至2017年间发表的随机对照研究、非对照研究、荟萃分析和系统性综述。结果如下：N-乙酰半胱氨酸对表皮脱落症、咬甲症、刮毛癖、寻常痤疮、I型板层状鱼鳞病、大疱性硬斑病、系统性硬化症、中毒性表皮坏死松解症、特应性皮炎、着色性干皮病和假卟啉症的疗效。研究还显示了在伤口愈合和光保护方面的益处。结论：现有文献的综述表明，N-乙酰半胱氨酸可能作为一种安全，耐受，有效的治疗选择，用于各种皮肤病。
Background: In recent studies, N-acetylcysteine has been shown to be efficacious in several dermatologic conditions. Objective: The aim was to review clinical trials that assess the efficacy of N-acetylcysteine in cutaneous disorders. Design: The PubMed database was searched and a manual search of clinical trials in the references was performed. Studies included randomized, controlled studies, uncontrolled studies, meta-analyses, and systemic reviews published between years 1966 and 2017. Results: Efficacy of N-acetylcysteine was shown in excoriation disorder, onychophagia disorder, trichotillomania, acne vulgaris, Type I lamellar ichthyosis, bullous morphea, systemic sclerosis, toxic epidermal necrolysis, atopic dermatitis, xeroderma pigmentosum, and pseudoporphyria. Studies also show benefits in wound healing and photoprotection. Conclusion: The review of available literature suggests that N-acetylcysteine could potentially serve as a safe, tolerable, and effective therapeutic option for a variety of dermatologic conditions.