The influence of comorbid depression on quality of life for people with epilepsy
The influence of comorbid depression on quality of life for people with epilepsy
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DOI：
10.1016/j.yebeh.2003.07.009
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发表时间：
2003-10-01
影响因子：
2.6
通讯作者：
Fanning, K
中科院分区：
文献类型：
--
作者：
Cramer, JA;Blum, D;Fanning, K
通过邮政调查评估癫痫患者的HRQOL、抑郁和癫痫发作严重程度，评估抑郁对健康相关生活质量（HRQOL）的影响（N = 501）。所有类型癫痫发作的QOLIE-89评分均因共病性抑郁而显著降低（均P < 0.0001）。重度、部分性和轻度癫痫发作的患者如果患有轻中度或重度抑郁症，其HRQOL明显较差（均P < 0.0001）。最近有任何类型癫痫发作的人在所有领域的HRQOL都明显比3个月没有癫痫发作的人差。各组间抑郁类型差异有临床意义（> 12分）。抑郁（r = -0.72）、癫痫发作麻烦（r = -0.54）、癫痫发作严重程度（r = -0.37）和癫痫发作致残天数（r = -0.65）与所有领域较差的HRQOL均显著相关（所有亚量表P < 0.0001）。在所有类型的癫痫发作患者中，临床抑郁症与较差的HRQOL显著相关。(C) 2003 Elsevier Inc.版权所有。
The impact of depression on health-related quality of life (HRQOL) for people with epilepsy was evaluated using a postal survey that assessed HRQOL, depression, and seizure severity (N = 501). QOLIE-89 scores were significantly reduced by comorbid depression (all P < 0.0001) for all types of seizures. People with predominantly major, partial, and minor seizures had significantly poorer HRQOL if they had mild-moderate or major depression (all P < 0.0001). People with any type of recent seizure had significantly poorer HRQOL in all domains than people who were seizure-free for 3 months. Differences between groups by depression category were clinically significant (> 12 points). Depression (r = -0.72), seizure bothersomeness (r = -0.54), seizure severity (r = -0.37), and days disabled with seizures (r = -0.65) were significantly correlated with poorer HRQOL in all domains than found for nondepressed patients (all subscales P < 0.0001). Clinical depression is significantly associated with poorer HRQOL among people with all types of seizures. (C) 2003 Elsevier Inc. All rights reserved.