Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense
Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense
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DOI：
10.1248/cpb.54.745
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发表时间：
2006-05-01
影响因子：
1.7
通讯作者：
Chantrapromma, Kan
中科院分区：
文献类型：
--
作者：
Laphookhieo, Surat;Syers, John Keith;Chantrapromma, Kan
从木豆根中分离得到一个新的异戊烯基氧杂蒽酮化合物5-O-甲基celebixanthone（1），以及6个已知化合物celebixanthone（2），1，3，7-trihydroxy-2，4-di（3-methylbutan-2-enyl）xanthone（3），cochinone A（4），alpha-mangostin（5），beta-mangostin（6）和cochinone C（7）。通过波谱方法鉴定了它们的结构。化合物2和4-7显示出对人肺癌细胞系（NCI-H187）的细胞毒活性，IC 50值范围为0.65 - 5.2 μ g/ml。化合物1、2、6和7也显示出抗恶性疟原虫的抗疟活性，其IC 50值分别为3.2、4.9、7.2和2.6 μ g/ml。
A new prenylated xanthone, 5-O-methylcelebixanthone (1), together with six known compounds; celebixanthone (2), 1,3,7-trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone (3), cochinchinone A (4), alpha-mangostin (5), beta-mangostin (6) and cochinchinone C (7) were isolated from roots of Cratoxylum cochinchinense. Their structures were elucidated by spectroscopic methods. Compounds 2 and 4-7 showed cytotoxic activity against the human lung cancer cell line (NCI-H187) with IC50 values ranging from 0.65 to 5.2 mu g/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC50 values of 3.2, 4.9, 7.2 and 2.6 mu g/ml, respectively.