Disintegration of Multisensory Signals from the Real Hand Reduces Default Limb Self-Attribution: An fMRI Study
Disintegration of Multisensory Signals from the Real Hand Reduces Default Limb Self-Attribution: An fMRI Study
复制标题
DOI：
10.1523/jneurosci.1363-13.2013
复制
发表时间：
2013-08-14
影响因子：
5.3
通讯作者：
Ehrsson, H. Henrik
中科院分区：
文献类型：
--
作者：
Gentile, Giovanni;Guterstam, Arvid;Ehrsson, H. Henrik
我们的肢体在空间中的感知是建立在视觉、触觉和本体感觉信号的整合之上的。越来越多的证据表明，这些信号在运动前皮层、顶叶皮层和小脑皮层结合在一起。然而，这些区域的神经元群是否根据多感觉整合的基本时间和空间一致性原则来整合手势信号仍有待确定。在这里，我们开发了一种基于先进3D视频技术的设置，使我们能够在fMRI期间操纵传递给健康人类参与者的真实手部的视觉（VT）刺激的时空关系，并研究随后的神经和感知相关性。我们的实验有两个新发现。首先，我们发现运动前区、顶叶区和小脑区的反应依赖于VT刺激的空间和时间一致性。这种多感觉整合效应要求手的视觉和感觉姿势之间同时匹配，这表明来自上肢的一致的视觉本体感觉信号对于成功的VT整合至关重要。其次，我们观察到，多感官冲突显著破坏了对看到的真实肢体的所有权的默认感觉，这是通过互补的主观、心理生理和BOLD测量得出的。自我归因受损的程度可以通过关键多感觉区神经反应的衰减来预测。这些结果根据基本的时空原理阐明了多感觉手信号整合的神经基础，并表明这些信号的分解导致了对看到的真手的“剥夺”。
The perception of our limbs in space is built upon the integration of visual, tactile, and proprioceptive signals. Accumulating evidence suggests that these signals are combined in areas of premotor, parietal, and cerebellar cortices. However, it remains to be determined whether neuronal populations in these areas integrate hand signals according to basic temporal and spatial congruence principles of multisensory integration. Here, we developed a setup based on advanced 3D video technology that allowed us to manipulate the spatiotemporal relationships of visuotactile (VT) stimuli delivered on a healthy human participant's real hand during fMRI and investigate the ensuing neural and perceptual correlates. Our experiments revealed two novel findings. First, we found responses in premotor, parietal, and cerebellar regions that were dependent upon the spatial and temporal congruence of VT stimuli. This multisensory integration effect required a simultaneous match between the seen and felt postures of the hand, which suggests that congruent visuoproprioceptive signals from the upper limb are essential for successful VT integration. Second, we observed that multisensory conflicts significantly disrupted the default feeling of ownership of the seen real limb, as indexed by complementary subjective, psychophysiological, and BOLD measures. The degree to which self-attribution was impaired could be predicted from the attenuation of neural responses in key multisensory areas. These results elucidate the neural bases of the integration of multisensory hand signals according to basic spatiotemporal principles and demonstrate that the disintegration of these signals leads to "disownership" of the seen real hand.