Hippocampal and prefrontal processing of network topology to simulate the future.
Hippocampal and prefrontal processing of network topology to simulate the future.
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DOI：
10.1038/ncomms14652
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发表时间：
2017-03-21
影响因子：
16.6
通讯作者：
Spiers HJ
中科院分区：
文献类型：
--
作者：
Javadi AH;Emo B;Howard LR;Zisch FE;Yu Y;Knight R;Pinelo Silva J;Spiers HJ
拓扑网络是我们城市和社会环境的核心。然而，目前尚不清楚大脑如何以及何时处理拓扑结构来指导日常生活中的未来行为。通过对人类和伦敦（英国）的fMRI模拟，我们发现，特别是当在城市导航过程中进入新的街道时，右侧海马后部活动指示了可用于未来旅行的局部拓扑连接数量的变化，右侧海马前部活动反映了所进入街道的整体特性。当被迫绕路需要重新规划到达目标的路线时，双侧下外侧前额叶前部的活动与宽度优先搜索未来路径的规划需求相匹配。这些结果有助于形成海马和前额叶区域如何支持导航、规划和未来模拟的模型。众所周知，海马体支持导航，但它如何处理可能的路径来帮助导航尚不清楚。在这里，Javadi等人表明，进入街道会驱动与未来路径数量相对应的海马活动，而前额叶活动则与路径规划需求相对应。
Topological networks lie at the heart of our cities and social milieu. However, it remains unclear how and when the brain processes topological structures to guide future behaviour during everyday life. Using fMRI in humans and a simulation of London (UK), here we show that, specifically when new streets are entered during navigation of the city, right posterior hippocampal activity indexes the change in the number of local topological connections available for future travel and right anterior hippocampal activity reflects global properties of the street entered. When forced detours require re-planning of the route to the goal, bilateral inferior lateral prefrontal activity scales with the planning demands of a breadth-first search of future paths. These results help shape models of how hippocampal and prefrontal regions support navigation, planning and future simulation. The hippocampus is known to support navigation, but how it processes possible paths to aid navigation is unknown. Here Javadi et al. show that entering streets drives hippocampal activity corresponding to the number of future paths, and that prefrontal activity corresponds to path-planning demands.