Italians do it worse. Montreal Cognitive Assessment (MoCA) optimal cut-off scores for people with probable Alzheimer's disease and with probable cognitive impairment
Italians do it worse. Montreal Cognitive Assessment (MoCA) optimal cut-off scores for people with probable Alzheimer's disease and with probable cognitive impairment
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DOI：
10.1007/s40520-017-0727-6
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发表时间：
2017-12-01
影响因子：
4
通讯作者：
Lancioni, Giulio E.
中科院分区：
文献类型：
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作者：
Bosco, Andrea;Spano, Giuseppina;Lancioni, Giulio E.
蒙特利尔认知评估（莫卡）是一项测试，为因衰老或神经退行性综合征而导致认知障碍的人提供简短的筛查。在意大利，与世界其他地区一样，已经开展了几项莫卡验证研究。这项研究在意大利首次比较了可能患有阿尔茨海默病（AD）的人与健康人的样本。该研究还比较了两个社区居住的老年参与者群体，他们有和没有可能的认知障碍，这是通过调整后的MMSE评分的两个截止点来区分的。所有比较均采用ROC统计。诊断可能AD的最佳截止值为莫卡评分ae14。区分可能的认知障碍的最佳截止值是莫卡评分ae17（与MMSE截止值23.8相关）。结果证实了意大利和其他国际验证研究之间存在的截止点的实质性差异，表明意大利在莫卡方面的表现似乎在全球范围内低于其他国家。人口特征可能解释了这些结果。
Montreal cognitive assessment (MoCA) is a test providing a brief screening for people with cognitive impairment due to aging or neurodegenerative syndromes. In Italy, as in the rest of the world, several validation studies of MoCA have been carried out. This study compared, for the first time in Italy, a sample of people with probable Alzheimer's Disease (AD) with healthy counterparts. The study also compared two community-dwelling groups of aged participants with and without probable cognitive impairment, as discriminated by two cut-off points of adjusted MMSE score. All the comparisons were carried out according to ROC statistics. Optimal cutoff for a diagnosis of probable AD was a MoCA score ae14. Optimal cutoff for the discrimination of probable cognitive impairment was a MoCA score ae17 (associated to MMSE cutoff of 23.8). Results confirm the substantial discrepancy in cut-off points existing between Italian and other international validation studies, showing that Italian performance on MoCA seems to be globally lower than that in other Countries. Characteristics of population might explain these results.