Size at birth and coronary artery disease in a population with high birth weight
Size at birth and coronary artery disease in a population with high birth weight
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DOI：
10.1093/ajcn/76.6.1290
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发表时间：
2002-12-01
影响因子：
7.1
通讯作者：
Benediktsson, R
中科院分区：
文献类型：
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作者：
Gunnarsdottir, I;Birgisdottir, BE;Benediktsson, R
背景：流行病学研究表明胎儿和儿童生长与后来的冠状动脉疾病（CAD）之间存在联系。成人体型对出生体型与CAD关系的影响尚未得到深入研究。目的：我们调查了出生体重较高、冠心病发病率和死亡率低于其他斯堪的纳维亚人群的出生和成年体型与冠心病之间的关系。设计：在1914年至1935年间，在大雷克雅未克地区出生的2399名男性和2376名女性中确定了致死性或非致死性CAD。出生尺寸数据来自国家档案馆。成人的人体测量数据来自随机前瞻性雷克雅未克研究。结果：男性CAD与出生长度呈负相关（趋势P = 0.029），但与出生体重或体重指数（kg/m(3)）无显著相关。与参照组（52.5-54.0厘米）的男性相比，出生时身材矮小（小于或等于50.5厘米）和成年后身材高大（175-180.5厘米或> 180.5厘米）的男性患CAD的比值比（95% CI）分别为1.9（1.1,3.1）和2.2（1.2,4.0）。女性的出生尺寸与CAD呈u型关系。结论：出生时体型对冠心病有影响，但随成年体型的改变而改变。这证实了环境因素在产前和产后都对CAD的发展起作用。冰岛人的大出生规模可能解释了冰岛冠心病发病率和死亡率低于其他白人的原因。
Background: Epidemiologic studies suggest a link between fetal and childhood growth and later coronary artery disease (CAD). The influence of adult body size on the relation between birth size and CAD has not been thoroughly studied.Objective: We investigated the association between birth and adult sizes and CAD within a population with higher birth weight and a lower incidence of and mortality rate from CAD than those seen in other Scandinavian populations.Design: Fatal or nonfatal CAD was ascertained in 2399 men and 2376 women born in the Greater Reykjavik area between 1914 and 1935. Birth size was obtained from the National Archives. Anthropometric measurements in adults were obtained from the randomized prospective Reykjavik Study.Results: CAD was inversely related to birth length (P for trend = 0.029) in men but was not significantly related to birth weight or ponderal index (kg/m(3)). In men who were born short (less than or equal to50.5 cm) and who became tall adults (either 175-180.5 or > 180.5 cm), the odds ratios (95% CI) for CAD were 1.9 (1.1, 3.1) and 2.2 (1.2, 4.0), respectively, when compared with men in the reference group (those born 52.5-54.0 cm long). A U-shaped relation between birth size and CAD was found for women.Conclusions: Size at birth has an effect on CAD, but the effect is modified by adult body size. This confirms that environmental factors operate in both the prenatal and postnatal periods with regard to the development of CAD. The large birth size seen among Icelanders may explain the lower incidence and mortality rate of CAD in Iceland than are seen in other white populations.